School of Physical Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.
State Key Laboratory of Bioorganic & Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
J Org Chem. 2023 Mar 3;88(5):3330-3334. doi: 10.1021/acs.joc.2c02882. Epub 2023 Feb 13.
-(2,6-Dimethylphenyl)--(pyridin-2-ylmethyl)oxalamide (DMPPO) was revealed to be a more effective ligand for copper-catalyzed coupling reaction of (hetero)aryl halides with 1-alkynes than previously reported ones. Only 3 mol % CuCl and DMPPO are required to make the coupling complete at 100 °C (for bromides) and 80 °C (for iodides). Both (hetero)aryl and alkyl substituted 1-alkynes worked well under these conditions, leading to the formation of internal alkynes in great diversity.
-(2,6-二甲基苯基)-(吡啶-2-基甲基)草酰胺(DMPPO)被证明是一种比以前报道的更有效的配体，用于铜催化(杂)芳基卤化物与 1-炔烃的偶联反应。在 100°C(溴化物)和 80°C(碘化物)下，仅需 3 mol%的 CuCl 和 DMPPO 即可使偶联完全完成。在这些条件下，(杂)芳基和烷基取代的 1-炔烃都能很好地反应，生成多种内部炔烃。
