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Specific O-glycans in the mechanosensory domain of glycoprotein Ibα are important for its stability and function.

作者信息

Wang Yingchun, Li Renhao

机构信息

Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322.

出版信息

Haematologica. 2023 Sep 1;108(9):2526-2530. doi: 10.3324/haematol.2022.281979.

DOI:10.3324/haematol.2022.281979
PMID:36779596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10483358/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f92/10483358/f9ba1b6f4ede/1082526.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f92/10483358/997ddc06fe56/1082526.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f92/10483358/f2afb80b6ccc/1082526.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f92/10483358/f9ba1b6f4ede/1082526.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f92/10483358/997ddc06fe56/1082526.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f92/10483358/f2afb80b6ccc/1082526.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f92/10483358/f9ba1b6f4ede/1082526.fig3.jpg

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1
Specific O-glycans in the mechanosensory domain of glycoprotein Ibα are important for its stability and function.糖蛋白Ibα机械感觉结构域中的特定O-聚糖对其稳定性和功能很重要。
Haematologica. 2023 Sep 1;108(9):2526-2530. doi: 10.3324/haematol.2022.281979.
2
Desialylation of -glycans on glycoprotein Ibα drives receptor signaling and platelet clearance.-糖蛋白 Ibα 上的 -聚糖去唾液酸化可驱动受体信号转导和血小板清除。
Haematologica. 2021 Jan 1;106(1):220-229. doi: 10.3324/haematol.2019.240440.
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Platelet interaction with von Willebrand factor is enhanced by shear-induced clustering of glycoprotein Ibα.血小板与血管性血友病因子的相互作用通过糖蛋白 Ibα 的切变诱导聚集而增强。
Haematologica. 2013 Nov;98(11):1810-8. doi: 10.3324/haematol.2013.087221. Epub 2013 Jun 10.
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Desialylation of O-glycans activates von Willebrand factor by destabilizing its autoinhibitory module.糖链去唾液酸化通过破坏其自身抑制模块使血管性血友病因子（von Willebrand factor，vWF）激活。
J Thromb Haemost. 2022 Jan;20(1):196-207. doi: 10.1111/jth.15528. Epub 2021 Sep 26.
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Identification of a novel 14-3-3zeta binding site within the cytoplasmic domain of platelet glycoprotein Ibalpha that plays a key role in regulating the von Willebrand factor binding function of glycoprotein Ib-IX.在血小板糖蛋白Ibalpha胞质结构域内鉴定出一个新的14-3-3zeta结合位点，该位点在调节糖蛋白Ib-IX的血管性血友病因子结合功能中起关键作用。
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Mocarhagin, a novel cobra venom metalloproteinase, cleaves the platelet von Willebrand factor receptor glycoprotein Ibalpha. Identification of the sulfated tyrosine/anionic sequence Tyr-276-Glu-282 of glycoprotein Ibalpha as a binding site for von Willebrand factor and alpha-thrombin.莫卡哈金，一种新型眼镜蛇毒金属蛋白酶，可裂解血小板血管性血友病因子受体糖蛋白Ibalpha。鉴定糖蛋白Ibalpha的硫酸化酪氨酸/阴离子序列Tyr-276-Glu-282作为血管性血友病因子和α-凝血酶的结合位点。
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Role of 14-3-3ζ in platelet glycoprotein Ibα-von Willebrand factor interaction-induced signaling.14-3-3ζ在血小板糖蛋白Ibα-血管性血友病因子相互作用诱导信号传导中的作用
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Platelet glycoprotein Ib beta/IX mediates glycoprotein Ib alpha localization to membrane lipid domain critical for von Willebrand factor interaction at high shear.血小板糖蛋白 Ibβ/IX 介导糖蛋白 Ibα 定位到膜脂域，该域对于高切变下 von Willebrand 因子相互作用至关重要。
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The cytoplasmic domain of glycoprotein (GP) Ibalpha constrains the lateral diffusion of the GP Ib-IX complex and modulates von Willebrand factor binding.糖蛋白（GP）Ibalpha的胞质结构域限制了GP Ib-IX复合物的侧向扩散，并调节血管性血友病因子的结合。
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Cytoplasmic truncation of glycoprotein Ib alpha weakens its interaction with von Willebrand factor and impairs cell adhesion.糖蛋白Ibα的细胞质截短会削弱其与血管性血友病因子的相互作用，并损害细胞黏附。
Biochemistry. 2003 Feb 25;42(7):2245-51. doi: 10.1021/bi026549n.

本文引用的文献

1
Differential regulation of the platelet GPIb-IX complex by anti-GPIbβ antibodies.抗 GPIbβ 抗体对血小板 GPIb-IX 复合物的差异调节。
J Thromb Haemost. 2021 Aug;19(8):2044-2055. doi: 10.1111/jth.15359. Epub 2021 May 20.
2
Structure-function of platelet glycoprotein Ib-IX.血小板糖蛋白Ib-IX的结构与功能
J Thromb Haemost. 2020 Dec;18(12):3131-3141. doi: 10.1111/jth.15035. Epub 2020 Aug 24.
3
Desialylation of -glycans on glycoprotein Ibα drives receptor signaling and platelet clearance.-糖蛋白 Ibα 上的 -聚糖去唾液酸化可驱动受体信号转导和血小板清除。
Haematologica. 2021 Jan 1;106(1):220-229. doi: 10.3324/haematol.2019.240440.
4
Unaccompanied mechanosensory domain mediates low expression of glycoprotein Ibα: implications for Bernard-Soulier syndrome.无伴机械感觉结构域介导糖蛋白Ibα的低表达：对伯纳德-索利尔综合征的影响。
J Thromb Haemost. 2020 Feb;18(2):510-517. doi: 10.1111/jth.14684. Epub 2019 Dec 22.
5
Blood group alters platelet binding kinetics to von Willebrand factor and consequently platelet function.血型改变血小板与 von Willebrand 因子的结合动力学，从而影响血小板功能。
Blood. 2019 Mar 21;133(12):1371-1377. doi: 10.1182/blood-2018-06-855528. Epub 2019 Jan 14.
6
Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells.糖链上的唾液酸化能保护血小板免受肝脏库普弗细胞的清除。
Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8360-8365. doi: 10.1073/pnas.1707662114. Epub 2017 Jul 17.
7
Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.通过膜机械感受器的剪切诱导展开实现血小板清除
Nat Commun. 2016 Sep 27;7:12863. doi: 10.1038/ncomms12863.
8
Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site.通过靶向糖蛋白Ibα的近膜区脱落切割位点特异性抑制其胞外域脱落
J Thromb Haemost. 2013 Dec;11(12):2155-62. doi: 10.1111/jth.12425.
9
Targeting platelet GPIbβ reduces platelet adhesion, GPIb signaling and thrombin generation and prevents arterial thrombosis.靶向血小板 GPIbβ 可减少血小板黏附、GPIb 信号转导和凝血酶生成，预防动脉血栓形成。
Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1221-9. doi: 10.1161/ATVBAHA.112.301013. Epub 2013 Apr 4.
10
Platelet biogenesis and functions require correct protein O-glycosylation.血小板的生物发生和功能需要正确的蛋白质 O-糖基化。
Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16143-8. doi: 10.1073/pnas.1208253109. Epub 2012 Sep 17.