Mouchizadeh J, Papanicolaou G, Fielding L P
Department of Surgery, Yale New Haven Hospital, Connecticut.
Dis Colon Rectum. 1987 Nov;30(11):858-62. doi: 10.1007/BF02555424.
Experience with pouch procedures in the quest for continence after total panproctocolectomy has been associated with significant reoperation rates, making these procedures suitable only for highly selected and motivated patients. The purpose of this study was to determine, in an acute dog model, the optimum configuration of a new continence mechanism consisting of a musculo-serosal window formed between the afferent and efferent loops of small bowel. The following geometric measures were varied: single or double window (efferent and afferent loops, respectively); percent circumference of bowel wall used for the window; and distance between pouch apex and window. Intraluminal pressure against volume infused in standard time was recorded. Four hundred seventy experiments in 47 pouches were conducted. The authors suggest that the optimal configuration for this "valve" is bowel circumference used for the window--50 to 60 percent on both the afferent and efferent loops, with a pouch-valve distance of 5 to 6 cm. It is concluded that a biologic valve obviating the need for a nipple may be possible. The geometric configuration has been defined and should be studied in a chronic animal model to determine long-term results.
在全直肠结肠切除术后寻求控便的回肠贮袋手术经验与显著的再次手术率相关,这使得这些手术仅适用于经过严格挑选且积极性高的患者。本研究的目的是在急性犬模型中确定一种新的控便机制的最佳构型,该机制由在小肠输入袢和输出袢之间形成的肌浆膜窗口组成。以下几何参数有所变化:单窗口或双窗口(分别为输出袢和输入袢);用于窗口的肠壁周长百分比;以及贮袋顶端与窗口之间的距离。记录在标准时间内注入液体时的腔内压力。对47个贮袋进行了470次实验。作者建议,这种“瓣膜”的最佳构型是:用于窗口的肠周长——输入袢和输出袢均为50%至60%,贮袋-瓣膜距离为5至6厘米。得出的结论是,有可能存在一种无需乳头的生物瓣膜。已经确定了几何构型,应在慢性动物模型中进行研究以确定长期结果。