Carvajal A, Franganillo A M, Alvarez F J
Department of Anatomy and Embryology, Faculty of Medicine, University of Valladolid, Spain.
Dev Pharmacol Ther. 1987;10(6):449-53. doi: 10.1159/000457777.
The effects of verapamil and nifedipine on K+-induced contractions were studied in the isolated ileum of newborn, 30-day-old and adult guinea pigs. Both verapamil and nifedipine inhibited the K+-induced contractions, with nifedipine demonstrating the highest activity. The tonic component of the K+ response was more affected by the calcium antagonists than the phasic component. No changes in sensitivity to verapamil and nifedipine were recorded during the first month of postnatal development, thus suggesting that the function of calcium channels involved in the response to K+ does not change during this period.
在新生、30日龄和成年豚鼠的离体回肠中研究了维拉帕米和硝苯地平对钾离子诱导收缩的影响。维拉帕米和硝苯地平均抑制钾离子诱导的收缩，其中硝苯地平活性最高。钾离子反应的强直成分比相位成分更易受钙拮抗剂的影响。在出生后第一个月的发育过程中，未记录到对维拉帕米和硝苯地平敏感性的变化，因此表明在此期间参与钾离子反应的钙通道功能未发生改变。
