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阿片类药物在慢性疼痛管理中的应用:2022年美国退伍军人事务部和美国国防部临床实践指南更新概要

The Use of Opioids in the Management of Chronic Pain: Synopsis of the 2022 Updated U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline.

作者信息

Sandbrink Friedhelm, Murphy Jennifer L, Johansson Melanie, Olson Juli L, Edens Ellen, Clinton-Lont Jamie, Sall James, Spevak Christopher

机构信息

National Pain Management, Opioid Safety, and Prescription Drug Monitoring Program, Veterans Health Administration, Washington DC VA Medical Center, and Department of Neurology, George Washington University, Washington, DC (F.S.).

Pain Management, Opioid Safety, and Prescription Drug Monitoring Program, Veterans Health Administration, Washington, DC (J.L.M.).

出版信息

Ann Intern Med. 2023 Mar;176(3):388-397. doi: 10.7326/M22-2917. Epub 2023 Feb 14.

Abstract

DESCRIPTION

In May 2022, leadership within the U.S. Department of Veterans Affairs (VA) and U.S. Department of Defense (DoD) approved a joint clinical practice guideline for the use of opioids when managing chronic pain. This synopsis summarizes the recommendations that the authors believe are the most important to highlight.

METHODS

In December 2020, the VA/DoD Evidence-Based Practice Work Group assembled a team to update the 2017 VA/DoD Clinical Practice Guideline for Opioid Therapy for Chronic Pain. The guideline development team included clinical stakeholders and conformed to the National Academy of Medicine's tenets for trustworthy clinical practice guidelines. The guideline team developed key questions to guide a systematic evidence review that was done by an independent third party and distilled 20 recommendations for care using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. The guideline team also created 3 one-page algorithms to help guide clinical decision making. This synopsis presents the recommendations and highlights selected recommendations on the basis of clinical relevance.

RECOMMENDATIONS

This guideline is intended for clinicians who may be considering opioid therapy to manage patients with chronic pain. This synopsis reviews updated recommendations for the initiation and continuation of opioid therapy; dose, duration, and taper of opioids; screening, assessment, and evaluation; and risk mitigation. New additions are highlighted, including recommendations about the use of buprenorphine instead of full agonist opioids; assessing for behavioral health conditions and factors associated with higher risk for harm, such as pain catastrophizing; and the use of pain and opioid education to reduce the risk for prolonged opioid use for postsurgical pain.

摘要

描述

2022年5月,美国退伍军人事务部(VA)和美国国防部(DoD)的领导层批准了一项关于在慢性疼痛管理中使用阿片类药物的联合临床实践指南。本摘要总结了作者认为最重要的突出建议。

方法

2020年12月,VA/DoD循证实践工作组组建了一个团队,以更新2017年VA/DoD慢性疼痛阿片类药物治疗临床实践指南。指南制定团队包括临床利益相关者,并符合美国国家医学院关于可信临床实践指南的原则。指南团队提出了关键问题,以指导由独立第三方进行的系统证据审查,并使用GRADE(推荐分级评估、制定和评价)系统提炼出20条护理建议。指南团队还创建了3个单页算法,以帮助指导临床决策。本摘要介绍了这些建议,并根据临床相关性突出了选定的建议。

建议

本指南适用于可能考虑使用阿片类药物治疗慢性疼痛患者的临床医生。本摘要回顾了阿片类药物治疗起始和持续、阿片类药物剂量、持续时间和减量、筛查、评估和评价以及风险降低方面的更新建议。突出了新增内容,包括关于使用丁丙诺啡而非完全激动剂阿片类药物;评估行为健康状况和与更高伤害风险相关的因素,如疼痛灾难化;以及使用疼痛和阿片类药物教育来降低术后疼痛长期使用阿片类药物的风险。

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