雄激素性脱发在跨性别和性别多样化人群中的发病率：一项回顾性对比队列研究。
Androgenetic alopecia incidence in transgender and gender diverse populations: A retrospective comparative cohort study.
机构信息
Fenway Institute, Fenway Health, Boston, Massachusetts; Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Department of Medicine, Dartmouth Health, Lebanon, New Hampshire; George Washington University School of Medicine and Health Sciences, Washington, DC.
Fenway Institute, Fenway Health, Boston, Massachusetts; Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; New York Institute College of Osteopathic Medicine, Jonesboro, Arkansas.
出版信息
J Am Acad Dermatol. 2023 Sep;89(3):504-510. doi: 10.1016/j.jaad.2023.01.037. Epub 2023 Feb 11.
BACKGROUND
Androgenetic alopecia (AGA) is a significant challenge for many transgender and gender diverse (TGD) patients, but the rate of AGA among TGD patients receiving gender-affirming hormone therapy (GAHT) compared to cisgender patients has not yet been studied on a large scale.
OBJECTIVE
We examined the incidence of AGA among TGD patients receiving GAHT compared to cisgender patients.
METHODS
Retrospective cohort study using electronic health records from 37,826 patients seen at Fenway Health between August 1, 2014, and August 1, 2020. Crude and adjusted incidence rate ratios (aIRR) for AGA were calculated using Poisson regression.
RESULTS
TGD patients receiving masculinizing GAHT had aIRR 2.50, 95% CI 1.71-3.65 and 1.30, 95% CI 0.91-1.86 compared to cisgender women and cisgender men, respectively. The rate of AGA for TGD patients receiving feminizing GAHT was not significantly different compared to cisgender men but was significantly increased compared to cisgender women (aIRR 1.91, 95% CI 1.25-2.92).
LIMITATIONS
Inability to determine causation and limited generalizability.
CONCLUSION
TGD patients receiving masculinizing GAHT have 2.5 times the rate of AGA compared to cisgender women, whereas TGD patients on feminizing GAHT did not have a significantly increased rate of AGA compared to cisgender men.
背景
雄激素性脱发（AGA）是许多跨性别和性别多样化（TGD）患者面临的重大挑战，但接受性别肯定激素治疗（GAHT）的 TGD 患者与顺性别患者相比，AGA 的发生率尚未在大规模研究中进行研究。
目的
我们研究了接受 GAHT 的 TGD 患者与顺性别患者相比，AGA 的发生率。
方法
使用 Fenway Health 于 2014 年 8 月 1 日至 2020 年 8 月 1 日期间的电子健康记录进行回顾性队列研究。使用泊松回归计算 AGA 的粗发病率比（aIRR）和调整发病率比（aIRR）。
结果
接受男性化 GAHT 的 TGD 患者的 aIRR 分别为 2.50（95%CI 1.71-3.65）和 1.30（95%CI 0.91-1.86），与顺性别女性和男性相比。接受女性化 GAHT 的 TGD 患者的 AGA 发生率与顺性别男性相比无显著差异，但与顺性别女性相比显著增加（aIRR 1.91，95%CI 1.25-2.92）。
局限性
无法确定因果关系和有限的普遍性。
结论
接受男性化 GAHT 的 TGD 患者的 AGA 发生率是顺性别女性的 2.5 倍，而接受女性化 GAHT 的 TGD 患者的 AGA 发生率与顺性别男性相比没有显著增加。
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