Caligiuri M P, Abbs J H
Research Service, Veterans Administration Medical Center, San Diego, California.
Exp Neurol. 1987 Dec;98(3):563-72. doi: 10.1016/0014-4886(87)90265-2.
Analyses of the response magnitudes of the short-latency perioral reflex were made in a group of Parkinson disease patients and control subjects. As a group, the parkinsonian subjects manifested reflex magnitudes which were increased relative to normal. For low-acceleration, mechanical displacements of perioral tissue (less than 500 cm/s2), the perioral reflex was not elicited in normal controls. However, such low-acceleration stimuli did elicit the perioral reflex in more than half of the parkinsonian subjects studied. These findings are consistent with earlier findings of increased sensitivity of facial and perioral reflexes associated with disturbances of the basal ganglia. These results contribute to the understanding of specific stimulus-response characteristics of the facial reflex and the role of the basal ganglia in orofacial motor control. The finding of increased sensitivity to mechanical stimuli in Parkinson's disease supports the hypothesis of basal ganglia gating or regulation of afferent information.
对一组帕金森病患者和对照受试者进行了短潜伏期口周反射反应幅度的分析。作为一个群体，帕金森病受试者表现出相对于正常情况增加的反射幅度。对于低加速度（口周组织的机械位移小于500厘米/秒²），正常对照中未引出口周反射。然而，在超过一半的所研究帕金森病受试者中，这种低加速度刺激确实引出了口周反射。这些发现与早期关于与基底神经节功能障碍相关的面部和口周反射敏感性增加的发现一致。这些结果有助于理解面部反射的特定刺激-反应特征以及基底神经节在口面部运动控制中的作用。帕金森病中对机械刺激敏感性增加的发现支持了基底神经节对传入信息进行门控或调节的假说。
