Department of Neurology, Severance Hospital, Yonsei University, Seoul, Korea.
Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2023 Feb 13;38(6):e31. doi: 10.3346/jkms.2023.38.e31.
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common type of autoimmune encephalitis. Approximately 80% of patients with anti-NMDAR encephalitis are women. Tumors are detected in approximately 50% of female patients with anti-NMDAR encephalitis, of which 96% are ovarian teratomas. We describe the case of a 28-year-old woman diagnosed with anti-NMDAR encephalitis with mediastinal and bilateral ovarian teratomas in July 2019. The patient recovered following surgical management of the mediastinal mass and both ovarian teratomas, and immunotherapy. This case shows that teratomas can be found at multiple sites other than ovaries. Therefore, detecting teratomas using whole-body evaluation may be helpful for diagnosis and treatment.
抗 N-甲基-D-天冬氨酸受体(NMDAR)脑炎是最常见的自身免疫性脑炎类型。大约 80%的抗 NMDAR 脑炎患者为女性。约 50%的女性抗 NMDAR 脑炎患者可检测到肿瘤,其中 96%为卵巢畸胎瘤。我们描述了一例 28 岁女性患者,该患者于 2019 年 7 月被诊断为抗 NMDAR 脑炎合并纵隔和双侧卵巢畸胎瘤。该患者在接受纵隔肿块和双侧卵巢畸胎瘤的手术治疗以及免疫治疗后恢复良好。本病例表明畸胎瘤可发生于卵巢以外的多个部位。因此,使用全身评估检测畸胎瘤可能有助于诊断和治疗。