抗 N-甲基-D-天冬氨酸受体脑炎（Anti-NMDAR 脑炎）合并卵巢黏液性囊腺瘤 1 例报告
The first case of Anti-N-methyl-d-aspartate receptor encephalitis (Anti-NMDAR encephalitis) associated with ovarian mucinous cystadenoma: A case report.
机构信息
Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University, College of Medicine, South Korea.
Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University, College of Medicine, South Korea; Paik Institute for Clinical Research, Inje University, College of Medicine, South Korea.
出版信息
Taiwan J Obstet Gynecol. 2019 Jul;58(4):557-559. doi: 10.1016/j.tjog.2019.05.022.
OBJECTIVE
Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is a rare autoimmune and paraneoplastic encephalitis caused by the N-methyl-d-aspartate receptor antibody which is related to tumors, such as teratomas of the ovaries. To our knowledge, this is the first reported case of Anti-NMDAR encephalitis associated with ovarian mucinous cystadenoma.
CASE REPORT
A 23-year-old woman with a flu-like illness, confused mental status, and behavioral changes presented to the hospital. A right-sided ovarian tumor was detected during the work-up and was suspected to be a teratoma that might have caused the encephalitis. A laparoscopic right salpingo-oophorectomy (RSO) was performed. Histopathological examination revealed a mucinous cystadenoma. She recovered gradually and had complete resolution of symptoms after surgical removal of the mucinous cystadenoma and immunotherapy.
CONCLUSION
Even though anti-NMDAR encephalitis is caused by ovarian teratoma because it contains various types of tissues, ovarian tumors in anti-NMDAR encephalitis may not be limited to ovarian teratomas.
目的
抗 N-甲基-D-天冬氨酸受体（anti-NMDAR）脑炎是一种罕见的自身免疫性和副肿瘤性脑炎，由 N-甲基-D-天冬氨酸受体抗体引起，与肿瘤有关，如卵巢畸胎瘤。据我们所知，这是首例报道的抗 NMDAR 脑炎与卵巢黏液性囊腺瘤相关的病例。
病例报告
一名 23 岁女性因流感样疾病、意识混乱和行为改变就诊。在检查过程中发现右侧卵巢肿瘤，怀疑是引起脑炎的畸胎瘤。进行了腹腔镜右侧输卵管卵巢切除术（RSO）。组织病理学检查显示为黏液性囊腺瘤。在黏液性囊腺瘤切除和免疫治疗后，她逐渐恢复，症状完全缓解。
结论
尽管抗 NMDAR 脑炎是由卵巢畸胎瘤引起的，因为它包含各种类型的组织，但抗 NMDAR 脑炎中的卵巢肿瘤可能不仅限于卵巢畸胎瘤。
Zotero 插件