抗 N-甲基-D-天冬氨酸受体脑炎（Anti-NMDAR 脑炎）合并卵巢黏液性囊腺瘤 1 例报告

The first case of Anti-N-methyl-d-aspartate receptor encephalitis (Anti-NMDAR encephalitis) associated with ovarian mucinous cystadenoma: A case report.

机构信息

Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University, College of Medicine, South Korea.

Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University, College of Medicine, South Korea; Paik Institute for Clinical Research, Inje University, College of Medicine, South Korea.

出版信息

Taiwan J Obstet Gynecol. 2019 Jul;58(4):557-559. doi: 10.1016/j.tjog.2019.05.022.

DOI:10.1016/j.tjog.2019.05.022

PMID:31307751

Abstract

OBJECTIVE

Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is a rare autoimmune and paraneoplastic encephalitis caused by the N-methyl-d-aspartate receptor antibody which is related to tumors, such as teratomas of the ovaries. To our knowledge, this is the first reported case of Anti-NMDAR encephalitis associated with ovarian mucinous cystadenoma.

CASE REPORT

A 23-year-old woman with a flu-like illness, confused mental status, and behavioral changes presented to the hospital. A right-sided ovarian tumor was detected during the work-up and was suspected to be a teratoma that might have caused the encephalitis. A laparoscopic right salpingo-oophorectomy (RSO) was performed. Histopathological examination revealed a mucinous cystadenoma. She recovered gradually and had complete resolution of symptoms after surgical removal of the mucinous cystadenoma and immunotherapy.

CONCLUSION

Even though anti-NMDAR encephalitis is caused by ovarian teratoma because it contains various types of tissues, ovarian tumors in anti-NMDAR encephalitis may not be limited to ovarian teratomas.

摘要