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发作性睡病性头痛——2022 年我们了解多少?

Hypnic Headache - What do we know in 2022?

机构信息

Department of Neurology, Westgerman Headache Center Essen, University Hospital Essen, Essen, Germany.

出版信息

Cephalalgia. 2023 Mar;43(3):3331024221148659. doi: 10.1177/03331024221148659.

DOI:10.1177/03331024221148659
PMID:36786376
Abstract

BACKGROUND

Hypnic Headache, also known as "alarm clock headache", is a rare primary headache disorder. It is characterized by frequently recurring headache attacks, which only develop during sleep, especially nighttime sleep.

OBJECTIVE

This article gives a narrative review on the current knowledge about Hypnic Headache with a focus on secondary Hypnic Headache.

METHODS

Based on literature research, using Pubmed and Google Scholar, latest case reports, studies, and systematic reviews about Hypnic Headache were analyzed and summarized focusing on therapeutic options and causes of secondary Hypnic Headache.

CONCLUSION

Hypnic Headache mainly occurs in elderly patients. However, younger patients and children may also suffer from Hypnic Headache. Many different causes of secondary Hypnic Headache are described in the literature and ought to be ruled out before diagnosing primary Hypnic Headache. The pathophysiology of primary Hypnic Headache remains unclear, but a dysfunction of the hypothalamus seems to play a key role.

摘要

背景

催眠性头痛,又称“闹钟头痛”,是一种罕见的原发性头痛疾病。其特征是频繁反复发作的头痛,仅在睡眠时发生,尤其是夜间睡眠时。

目的

本文对催眠性头痛的现有知识进行了叙述性综述,重点介绍了继发性催眠性头痛。

方法

基于文献研究,使用 Pubmed 和 Google Scholar,对最新的关于催眠性头痛的病例报告、研究和系统综述进行了分析和总结,重点关注治疗选择和继发性催眠性头痛的病因。

结论

催眠性头痛主要发生在老年患者中。然而,年轻患者和儿童也可能患有催眠性头痛。继发性催眠性头痛有许多不同的病因在文献中被描述,在诊断原发性催眠性头痛之前应该排除这些病因。原发性催眠性头痛的病理生理学仍不清楚,但下丘脑功能障碍似乎起着关键作用。

相似文献

1
Hypnic Headache - What do we know in 2022?发作性睡病性头痛——2022 年我们了解多少?
Cephalalgia. 2023 Mar;43(3):3331024221148659. doi: 10.1177/03331024221148659.
2
Hypnic headache.催眠性头痛。
Cephalalgia. 2013 Dec;33(16):1349-57. doi: 10.1177/0333102413495967. Epub 2013 Jul 5.
3
Epidemiology and clinical features of hypnic headache: A systematic review and meta-analysis.催眠性头痛的流行病学和临床特征:系统评价和荟萃分析。
Cephalalgia. 2023 Dec;43(12):3331024231218389. doi: 10.1177/03331024231218389.
4
Hypnic headache - a rare primary headache disorder with very good response to indomethacin.睡眠性头痛——一种罕见的原发性头痛疾病,对消炎痛反应良好。
Neuro Endocrinol Lett. 2012;33(6):597-9.
5
Hypnic headache.催眠性头痛。
Curr Pain Headache Rep. 2010 Aug;14(4):309-15. doi: 10.1007/s11916-010-0124-8.
6
Clinical features, polysomnography and outcome in patients with hypnic headache.睡眠性头痛患者的临床特征、多导睡眠图及预后
Cephalalgia. 2008 Mar;28(3):209-15. doi: 10.1111/j.1468-2982.2007.01496.x.
7
Secondary "hypnic headache".继发性“睡眠性头痛”。
J Neurol. 2007 May;254(5):646-54. doi: 10.1007/s00415-006-0424-4. Epub 2007 Apr 3.
8
Pathophysiology of hypnic headache.睡眠性头痛的病理生理学
Cephalalgia. 2014 Sep;34(10):806-12. doi: 10.1177/0333102414535996. Epub 2014 May 29.
9
Hypnic headache: a review of clinical features, therapeutic options and outcomes.睡眠性头痛:临床特征、治疗选择及预后综述
Cephalalgia. 2014 Sep;34(10):795-805. doi: 10.1177/0333102414537914. Epub 2014 Jun 18.
10
Hypnic headache.催眠性头痛。
Expert Rev Neurother. 2010 Sep;10(9):1391-7. doi: 10.1586/ern.10.112.

引用本文的文献

1
Nighttime Primary Headaches in Children: Beyond Hypnic Headache, a Comprehensive Review.儿童夜间原发性头痛:除了睡眠性头痛之外的全面综述
Life (Basel). 2025 Jul 28;15(8):1198. doi: 10.3390/life15081198.
2
Pediatric hypnic headache: a systematic review.小儿睡眠性头痛:一项系统综述。
Front Neurol. 2023 Aug 11;14:1254567. doi: 10.3389/fneur.2023.1254567. eCollection 2023.
3
A Rare Case of Cluster Headache Occurring Exclusively During Sleep Without Autonomic Symptoms and Agitation: A Case Report and Literature Review.一例仅在睡眠期间发作且无自主神经症状及烦躁不安的丛集性头痛罕见病例:病例报告及文献综述
Cureus. 2023 May 15;15(5):e39021. doi: 10.7759/cureus.39021. eCollection 2023 May.