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本文引用的文献

1
Mutations in Confer Low-Level Resistance to Benzothiazinone DprE1 Inhibitors in Mycobacterium tuberculosis.突变使结核分枝杆菌中的 DprE1 苯并噻唑酮抑制剂产生低水平耐药性。
Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0090422. doi: 10.1128/aac.00904-22. Epub 2022 Aug 3.
2
The pipeline of new molecules and regimens against drug-resistant tuberculosis.针对耐药结核病的新分子和治疗方案研发流程
J Clin Tuberc Other Mycobact Dis. 2021 Nov 5;25:100285. doi: 10.1016/j.jctube.2021.100285. eCollection 2021 Dec.
3
Comparative Efficacy of the Novel Diarylquinoline TBAJ-876 and Bedaquiline against a Resistant Mutant in a Mouse Model of Tuberculosis.新型二芳基喹啉 TBAJ-876 与贝达喹啉对耐多药结核分枝杆菌感染小鼠模型的疗效比较。
Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0141221. doi: 10.1128/AAC.01412-21. Epub 2021 Sep 27.
4
OPC-167832, a Novel Carbostyril Derivative with Potent Antituberculosis Activity as a DprE1 Inhibitor.新型碳氮唑衍生物 OPC-167832 作为 DprE1 抑制剂具有强大的抗结核活性。
Antimicrob Agents Chemother. 2020 May 21;64(6). doi: 10.1128/AAC.02020-19.
5
Unexpected high prevalence of resistance-associated Rv0678 variants in MDR-TB patients without documented prior use of clofazimine or bedaquiline.在未记录有先前使用氯法齐明或贝达喹啉情况的耐多药结核病患者中，与耐药相关的Rv0678变体意外地具有高流行率。
J Antimicrob Chemother. 2017 Mar 1;72(3):684-690. doi: 10.1093/jac/dkw502.
6
1,4-azaindole, a potential drug candidate for treatment of tuberculosis.1,4-氮杂吲哚，一种治疗结核病的潜在候选药物。
Antimicrob Agents Chemother. 2014 Sep;58(9):5325-31. doi: 10.1128/AAC.03233-14. Epub 2014 Jun 23.
7
Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl ribose.癸异戊二烯基磷酸阿拉伯呋喃糖是分枝杆菌阿拉伯聚糖中D - 阿拉伯呋喃糖残基的供体，它通过癸异戊二烯基磷酸核糖的两步差向异构化反应形成。
J Bacteriol. 2005 Dec;187(23):8020-5. doi: 10.1128/JB.187.23.8020-8025.2005.

Mutations in Reduce Susceptibility of Mycobacterium tuberculosis to the DprE1 Inhibitor TBA-7371.

作者信息

Almeida Deepak V, Converse Paul J, Nuermberger Eric L

机构信息

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

出版信息

Antimicrob Agents Chemother. 2023 Mar 16;67(3):e0005223. doi: 10.1128/aac.00052-23. Epub 2023 Feb 14.

DOI:10.1128/aac.00052-23
PMID:36786606
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10019223/
Abstract
摘要