使用CFSONHNHBoc作为CF源的香豆素无催化剂电化学三氟甲基化反应
Catalyst-free electrochemical trifluoromethylation of coumarins using CFSONHNHBoc as the CF source.
作者信息
Cen Nannan, Wang Han, Zhou YiCheng, Gong Ruoqu, Sui Dandan, Chen Wenbo
机构信息
Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, Shanghai University of Electric Power, Shanghai 200090, China.
CAS Key Laboratory of Energy Regulation Materials, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
出版信息
Org Biomol Chem. 2023 Mar 1;21(9):1883-1887. doi: 10.1039/d2ob01925f.
An efficient electrochemical trifluoromethylation of coumarins using CFSONHNHBoc as the source of the trifluoromethyl group was developed. Under catalyst-free and external oxidant-free electrolysis conditions, a range of 3-trifluoromethyl coumarins were obtained in moderate to good yields. The method could be easily scaled up with moderate efficiency.
开发了一种使用CFSONHNHBoc作为三氟甲基源的香豆素高效电化学三氟甲基化反应。在无催化剂和无外部氧化剂的电解条件下，以中等至良好的产率得到了一系列3-三氟甲基香豆素。该方法可以很容易地以中等效率进行放大。
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