使用 CFSONa 的 2-异氰基联苯的电化学三氟甲基化反应：6-(三氟甲基)菲啶的合成。
Electrochemical trifluoromethylation of 2-isocyanobiaryls using CFSONa: synthesis of 6-(trifluoromethyl)phenanthridines.
机构信息
Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand.
Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand.
出版信息
Org Biomol Chem. 2023 May 24;21(20):4225-4236. doi: 10.1039/d3ob00239j.
An efficient trifluoromethylation of 2-isocyanobiaryls was developed through the constant current electrolysis, employing sodium trifluoromethanesulfinate (CFSONa) as the trifluoromethyl source. The method enabled the syntheses of a series of 6-(trifluoromethyl)phenanthridine derivatives in moderate to high yields under metal- and oxidant-free conditions. A gram-scale synthesis highlights the synthetic versatility of the reported protocol.
通过恒流电解，以三氟甲磺酸纳（CFSONa）作为三氟甲基源，开发了一种高效的 2-异氰基联苯的三氟甲基化方法。该方法在无金属和氧化剂的条件下，以中等至较高的收率实现了一系列 6-（三氟甲基）菲啶衍生物的合成。克级规模的合成突出了所报道方法的合成多功能性。
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