Watanabe Y
First Department of Pathology, Nippon Medical School, Tokyo, Japan.
Gastroenterol Jpn. 1987 Oct;22(5):578-87. doi: 10.1007/BF02776717.
Experimental ischemic colitis proximal to artificial bowel obstruction was produced under poor regional circulatory conditions in rats. Only the vessels of the left hemi-colon were ligated to obtain poor circulation (ischemia). Two types of aluminum rings were used to obstruct the bowel at the most distal portion of the ischemic colon. One, with a 4 mm internal diameter, was used for the model of partial colon obstruction with ischemia (partial obstruction, n = 25) and the other, with a 2 mm internal diameter, was used for complete colon obstruction with ischemia (complete obstruction, n = 25). The circumference of the dilated bowel was larger in complete obstruction than in partial obstruction. Ischemic colitis developed in 9 of 25 rats (34.0%) with partial obstruction and 16 of 25 (64.0%) with complete obstruction. In terms of morphometry, over half of the ischemic lesions in complete obstruction were more than 1.0 cm2, but such a large size in partial obstruction was not observed. It was demonstrated that the depth of ischemic lesions gradually increased in extensive lesions. In conclusion, complete colon obstruction with ischemia frequently caused severer ischemic colitis, together with marked distention of the proximal bowel, than partial colon obstruction with ischemia.
在大鼠局部循环条件较差的情况下，制造人工肠梗阻近端的实验性缺血性结肠炎。仅结扎左半结肠血管以造成循环不良（缺血）。使用两种类型的铝环在缺血结肠的最远端阻塞肠道。一种内径为4毫米，用于部分结肠缺血性梗阻模型（部分梗阻，n = 25）；另一种内径为2毫米，用于完全结肠缺血性梗阻模型（完全梗阻，n = 25）。完全梗阻时扩张肠段的周长大于部分梗阻时。25只部分梗阻大鼠中有9只（34.0%）发生缺血性结肠炎，25只完全梗阻大鼠中有16只（64.0%）发生缺血性结肠炎。在形态学方面，完全梗阻中超过一半的缺血性病变面积超过1.0平方厘米，但部分梗阻中未观察到如此大面积的病变。结果表明，在广泛病变中，缺血性病变的深度逐渐增加。总之, 与部分结肠缺血性梗阻相比，完全结肠缺血性梗阻常导致更严重的缺血性结肠炎，同时近端肠管明显扩张。
