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慢性抗精神病药物使用情况下的粪性穿孔:一例报告

Stercoral Perforation in the Setting of Chronic Antipsychotic Use: A Case Report.

作者信息

Osman Masha, Fiorentino Michele, Gwiazdowski Michael, Gervasoni James E

机构信息

General Surgery, St. George's University School of Medicine, New York, USA.

Department of Surgery, Vanderbilt University Medical Center, Nashville, USA.

出版信息

Cureus. 2023 Jan 11;15(1):e33631. doi: 10.7759/cureus.33631. eCollection 2023 Jan.

DOI:10.7759/cureus.33631
PMID:36788819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9912131/
Abstract

Stercoral perforation is a rare form of colonic perforation with limited reports in the literature, accounting for less than 140 documented cases. This complication occurs due to increased intraluminal pressure created by fecal impaction, ultimately causing colonic ulceration and necrosis. It is most often seen in elderly or debilitated patients with chronic constipation. The long-term use of drugs or medications with side effects of chronic constipation such as opioids, antispasmodics, tricyclic antidepressants, and calcium channel blockers have been implicated in these cases. Here we present a case of stercoral perforation in a patient with short-term opioid use following an orthopedic procedure, but more likely complicated by long-term use of antipsychotics and antidepressants.

摘要

粪性穿孔是一种罕见的结肠穿孔形式,文献报道有限,记录在案的病例不到140例。这种并发症是由于粪块嵌塞导致肠腔内压力升高,最终引起结肠溃疡和坏死。它最常见于患有慢性便秘的老年或体弱患者。长期使用具有慢性便秘副作用的药物,如阿片类药物、抗痉挛药、三环类抗抑郁药和钙通道阻滞剂,与这些病例有关。在此,我们报告一例骨科手术后短期使用阿片类药物,但更可能因长期使用抗精神病药物和抗抑郁药物而并发粪性穿孔的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/022e/9912131/35d8d523f85b/cureus-0015-00000033631-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/022e/9912131/f1791875a3ec/cureus-0015-00000033631-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/022e/9912131/35d8d523f85b/cureus-0015-00000033631-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/022e/9912131/f1791875a3ec/cureus-0015-00000033631-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/022e/9912131/35d8d523f85b/cureus-0015-00000033631-i02.jpg

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