Asad Usman, Alkul Suzanne, Shimizu Ikue, Ranario Jennifer
Department of Dermatology, Baylor College of Medicine, Houston, USA.
Cureus. 2023 Jan 10;15(1):e33610. doi: 10.7759/cureus.33610. eCollection 2023 Jan.
Squamous cell carcinoma (SCC) is a malignancy that arises from keratinocytes of the epidermis. Cystic variants of several types of cutaneous neoplasms have been rarely described in the literature. We report a case of biopsy-proven, well-differentiated invasive SCC treated with Mohs surgery. On frozen sections, the pathology slides showed benign-appearing cystic structures in the margins that persisted after it had appeared that the original malignancy had been cleared. After taking another Mohs stage due to clinical suspicion, additional SCC was found and was subsequently cleared after two more Mohs stages. To the best of our knowledge, this is the first report to histologically demonstrate biopsy-proven invasive SCC with benign-appearing cystic structures on frozen sections.
鳞状细胞癌（SCC）是一种起源于表皮角质形成细胞的恶性肿瘤。文献中很少描述几种皮肤肿瘤的囊性变体。我们报告一例经活检证实的高分化浸润性SCC，采用莫氏手术治疗。在冰冻切片上，病理切片显示切缘有看似良性的囊性结构，在原恶性肿瘤似乎已被清除后这些结构仍然存在。由于临床怀疑又进行了一个莫氏手术阶段，发现了额外的鳞状细胞癌，随后又经过两个莫氏手术阶段将其清除。据我们所知，这是第一份在组织学上证明经活检证实的浸润性鳞状细胞癌在冰冻切片上有看似良性的囊性结构的报告。
