Kitamura Shun, Komiyama Kota, Yahagi Kazuyuki, Sekiguchi Masahiro, Ishizawa Taiki, Nonaka Hideaki, Nakase Masaaki, Horiuchi Yu, Asami Masahiko, Yuzawa Hitomi, Tanaka Jun, Aoki Jiro, Tanabe Kengo
Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan.
J Cardiol Cases. 2022 Oct 28;27(2):73-75. doi: 10.1016/j.jccase.2022.10.006. eCollection 2023 Feb.
Previous reports on cardiac intervention in cases with antithrombin deficiency are extremely limited. We report a case of acute coronary syndrome with antithrombin deficiency in a 62-year-old man with multiple histories of thrombosis. He had worsening chest pain, and laboratory data showed an elevated level of troponin T, suggesting acute myocardial infarction. Currently, there is no fixed anticoagulation strategy for coronary intervention in patients with antithrombin deficiency. In this case, we performed coronary intervention with heparin in addition to antithrombin concentrate. The intervention was successfully performed without thrombosis or bleeding complications.
Antithrombin deficiency is a rare disorder and data about coronary intervention for cases with antithrombin deficiency are limited. We successfully performed intervention with our anticoagulant management and it would be beneficial for future reference.
先前关于抗凝血酶缺乏症患者心脏介入治疗的报道极为有限。我们报告一例62岁有多次血栓形成病史的男性急性冠状动脉综合征合并抗凝血酶缺乏症的病例。他胸痛加重，实验室检查数据显示肌钙蛋白T水平升高，提示急性心肌梗死。目前，对于抗凝血酶缺乏症患者的冠状动脉介入治疗尚无固定的抗凝策略。在此病例中，我们除使用抗凝血酶浓缩物外还联合肝素进行了冠状动脉介入治疗。介入治疗成功实施，未出现血栓形成或出血并发症。
抗凝血酶缺乏症是一种罕见疾病，关于抗凝血酶缺乏症患者冠状动脉介入治疗的数据有限。我们通过抗凝管理成功实施了介入治疗，这将为未来提供有益参考。
