Chang Fei, Wu Chanyuan, Wang Tao, Wang Qian
Trainee Doctor at Peking Union Medical College Hospital, Beijing, China.
Department of Rheumatology and Clinical Immunology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.
Rheumatol Immunol Res. 2022 Oct 20;3(3):143-146. doi: 10.2478/rir-2022-0023. eCollection 2022 Oct.
Multicentric reticulohistiocytosis (MRH) is a rare disease of unknown pathogenesis, characterized by skin histiocytosis and destructive arthritis. The present study describes a 53-year-old woman who presented with rheumatoid arthritis (RA) and MRH, which is a clinically rare entity. Diagnosis of MRH was based on nodule pathology. Meanwhile, the patient had typical arthritis, was positive for serum anti-cyclic citrullinated peptide (anti-CCP) antibodies and synovitis confirmed by joint ultrasound, and was diagnosed with RA. Her symptoms resolved with glucocorticoids and methotrexate.
多中心网状组织细胞增生症（MRH）是一种发病机制不明的罕见疾病，其特征为皮肤组织细胞增生和破坏性关节炎。本研究描述了一名53岁女性，她同时患有类风湿关节炎（RA）和MRH，这在临床上是一种罕见的情况。MRH的诊断基于结节病理学检查。同时，该患者有典型的关节炎症状，血清抗环瓜氨酸肽（抗CCP）抗体呈阳性，关节超声证实存在滑膜炎，被诊断为RA。她的症状通过糖皮质激素和甲氨蝶呤得到缓解。
