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激活钙敏感受体抗体阳性自身免疫性甲状旁腺功能减退症中的癫痫发作及类固醇治疗优势:一例报告

Seizures in activating calcium-sensing receptor antibodies positive autoimmune hypoparathyroidism and preponderance of steroids therapy: A case report.

作者信息

Khan Qaisar Ali, Shahi Ameena, Shahi Alishba, Baqi Abdul, Tango Tamara, Verma Ravina, Hamid Asrah Abdul, Saravanan Priyadharshini, Alam Mazhar, Shinwari Ismail Khan, Ul Ain Hoor

机构信息

DHQ and Teaching Hospital KDA Kohat Kohat Pakistan.

Lady Reading Hospital Peshawar Peshawar Pakistan.

出版信息

Clin Case Rep. 2023 Feb 10;11(2):e6901. doi: 10.1002/ccr3.6901. eCollection 2023 Feb.

Abstract

A 55-year-old female patient presented with generalized tonic-clonic seizures. Laboratory evaluation revealed low calcium (4.9 mg/dl), low PTH (0.9 pg/ml), and positive activating CaSR antibodies. The condition was diagnosed as autoimmune hypoparathyroidism. Calcium and vitamin D supplements did not correct the patient's hypocalcemia. The addition of prednisone to vitamin supplements showed a better response and corrected the hypocalcemia. The patient remained in seizure-free for one year.

摘要

一名55岁女性患者出现全身性强直阵挛发作。实验室检查显示血钙低(4.9毫克/分升)、甲状旁腺激素低(0.9皮克/毫升),且钙敏感受体激活抗体呈阳性。该病症被诊断为自身免疫性甲状旁腺功能减退症。补钙和补充维生素D未能纠正患者的低钙血症。在补充维生素的基础上加用泼尼松显示出更好的效果,并纠正了低钙血症。患者一年内未再发作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4713/9913179/06f9d0897c0f/CCR3-11-e6901-g001.jpg

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