采用键合硅胶C18柱快速简便地从血浆或血清中提取氟哌啶醇，用于高效液相色谱分析。
A rapid and simplified extraction of haloperidol from plasma or serum with bond elut C18 cartridge for analysis by high performance liquid chromatography.
作者信息
Hayakari M, Hashimoto Y, Kita T, Murakami S
机构信息
Department of Legal Medicine, School of Medicine, Hirosaki University, Japan.
出版信息
Forensic Sci Int. 1987 Sep;35(1):73-81. doi: 10.1016/0379-0738(87)90025-9.
This method for the determination of haloperidol (HAL) in plasma is based on high-performance liquid chromatography (HPLC) with a reversed-phase column, ODS-C18. HAL is rapidly extracted from human plasma by using Bond Elut C18 cartridge and its recovery is over 90%. The mobile phase is a mixture of 1% acetate/acetonitrile/tetrahydrofuran/triethylamine (69.5: 28.2:1.9:0.4, by vol.). The method is rapid, simple and free from intereferences and gives good precision.
这种测定血浆中氟哌啶醇（HAL）的方法基于高效液相色谱（HPLC），采用反相柱ODS-C18。通过使用Bond Elut C18柱快速从人血浆中提取HAL，其回收率超过90%。流动相为1%乙酸盐/乙腈/四氢呋喃/三乙胺（体积比为69.5:28.2:1.9:0.4）的混合物。该方法快速、简便、无干扰且精密度良好。
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