Enantioselective dearomatization reactions of heteroarenes by anion-binding organocatalysis.

Catalytic asymmetric dearomatization of heteroaromatic compounds has received considerable attention in the last few years, since it allows for a fast expansion of the chemical space by converting relatively simple, flat molecules into complex, three dimensional structures with added value. Among different approaches, remarkable progress has been recently achieved by the development of organocatalytic dearomatization methods. In particular, the anion-binding catalysis technology has emerged as a potent alternative to metal catalysis, which together with the design of novel, tunable anion-receptor motifs, has provided new entries for the enantioselective dearomatization of heteroarenes through a chiral contact ion pair formation by activation of the electrophilic reaction partner. In this feature, we provide an overview of the different methodologies and advances in anion-binding catalyzed dearomatization reactions of different heteroarenes.