Department of Microbiology, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria.
National Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning, 530007, Guangxi, China.
Curr Microbiol. 2023 Feb 15;80(4):105. doi: 10.1007/s00284-023-03209-z.
The application of Caenorhabditis elegans as a pathogenic model has spanned decades. Its use for pathogenic mould modeling has been attracting some attention lately, though not without some reservations. Several studies have shown C. elegans to be a reliable model for evaluating moulds' virulence factors and patterns as well as for screening the pathogenicity of mutant strains alongside their parental/wild type and revertant/complementary strains. There is a very high degree of reported similarities between the virulence patterns demonstrated in C. elegans and those of other invertebrate and vertebrate models. We have here presented several works in which this nematode model was adopted for virulence evaluation, and other comparative research in which virulence in C. elegans model were juxtaposed with other models. We have further presented possible reasons why there might have been variations of virulence in a few cases, thereby validating C. elegans to be an effective and reliable tool in the study of pathogenic moulds.
秀丽隐杆线虫作为一种病原体模型的应用已经跨越了几十年。最近，人们开始关注将其用于致病性霉菌建模，尽管并非没有一些保留意见。几项研究表明，秀丽隐杆线虫是评估霉菌毒力因子和模式的可靠模型，也是筛选突变菌株与其亲本/野生型和回复/互补菌株致病性的可靠模型。在秀丽隐杆线虫中表现出的毒力模式与其他无脊椎动物和脊椎动物模型之间存在着高度相似性。我们在这里介绍了几篇采用这种线虫模型进行毒力评估的工作，以及其他将秀丽隐杆线虫模型中的毒力与其他模型进行比较的研究。我们进一步提出了在某些情况下毒力可能存在差异的可能原因，从而验证了秀丽隐杆线虫作为研究致病性霉菌的有效可靠工具。
