Shah Viral N, Vigers Tim, Pyle Laura, Calhoun Peter, Bergenstal Richard M
Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Jaeb Center for Health Research, Tampa, Florida, USA.
Diabetes Technol Ther. 2023 May;25(5):324-328. doi: 10.1089/dia.2022.0544. Epub 2023 Mar 3.
In recent years, continuous glucose monitor (CGM) use is increasing in people without diabetes to promote healthy lifestyle. CGM metrics such as glucose management indicator (GMI), a statistical formula to estimate glycated hemoglobin (HbA1c) from sensor glucose, is commonly used to approximate HbA1c. This study was aimed to evaluate discordance between GMI and HbA1c in people without diabetes. Children and nonpregnant adults (age ≥6 years) without diabetes (laboratory HbA1c <5.7% and negative islet antibodies) were invited to participate in a multicenter prospective study aimed to evaluate glycemic profiles in nondiabetic individuals. Each participant wore a blinded Dexcom G6 for up to 10 days. GMI was calculated from mean sensor glucose and discordance between GMI and HbA1c was analyzed. Of 201 screened participants, 153 participants (mean age 31.2 ± 21.0 years, 66.0% female, HbA1c 5.1% ± 0.3%) were included in the analysis. Mean GMI was 0.59% higher than laboratory HbA1c in participants without diabetes. The discordance between GMI and HbA1c of 0.4% or greater was 71% in participants without diabetes compared with 39% in the original GMI development cohort. GMI does not accurately estimate HbA1c in healthy people without diabetes. Clinical trial registration number is: NCT00717977.
近年来，在没有患糖尿病的人群中，持续葡萄糖监测（CGM）的使用正在增加，以促进健康的生活方式。CGM指标，如葡萄糖管理指标（GMI），一种从传感器葡萄糖估计糖化血红蛋白（HbA1c）的统计公式，通常用于估算HbA1c。本研究旨在评估无糖尿病患者中GMI与HbA1c之间的不一致性。邀请没有糖尿病（实验室HbA1c<5.7%且胰岛抗体阴性）的儿童和非妊娠成年人（年龄≥6岁）参加一项多中心前瞻性研究，旨在评估非糖尿病个体的血糖谱。每位参与者佩戴盲法德康G6长达10天。根据平均传感器葡萄糖计算GMI，并分析GMI与HbA1c之间的不一致性。在201名筛查参与者中，153名参与者（平均年龄31.2±21.0岁，66.0%为女性，HbA1c 5.1%±0.3%）纳入分析。在无糖尿病参与者中，平均GMI比实验室HbA1c高0.59%。无糖尿病参与者中GMI与HbA1c的不一致性为0.4%或更高的比例为71%，而在原始GMI开发队列中这一比例为39%。GMI不能准确估计无糖尿病健康人群的HbA1c。临床试验注册号为：NCT00717977。
