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拇外翻手术中改善术后镇痛:通过添加单一透皮芬太尼贴剂抑制口服阿片类药物:一项前瞻性评估。

Improving postoperative analgesia in hallux valgus surgery: oral opioids suppression by addition of a single transdermal fentanyl patch: a prospective evaluation.

作者信息

Vandeputte Geoffroy, Eeckhoudt Annelies, Van Opstal Nick, Victor Jan

出版信息

Acta Orthop Belg. 2022 Sep;88(3):575-580. doi: 10.52628/88.3.10258.

Abstract

The last decade there is an exponential increase in opioid related deaths. This is proven to be correlated with the rising medical prescription rates of strong opioids. We investigated whether pain after hallux valgus surgery under popliteal nerve block could be adequately controlled without the prescription of oral opioids, with a single transdermal fentanyl patch. In this prospective observational study with 100 patients undergoing corrective first metatarsal osteotomies we prospectively investigated the adverse effects and need for extra pain medication. The transdermal fentanyl patch was applied one hour before surgery, prior to the ultrasound guided popliteal nerve block. Patients filled out a questionnaire every 6 hours to evaluate the pain [VAS-score], nausea [PONV-score], activity [acivity and ambulation score] and the intake of extra medication. Postoperative pain was well controlled [Mean VAS 2,53]. The maximum mean VAS score [3.93] was recorded 36 hours postoperatively. 63.8% of patients had less pain than expected. No major adverse effects were reported by the patients. Nausea was mainly mild and the majority of patients reported 'no effect' or 'sometimes' effect on daily activities. In an era where surgeons need to be aware of the threat of overuse of strong opioids, the use of a single transdermal fentanyl patch in combination with an ultrasound guided nerve block can be a good alternative in hallux valgus surgery. The use of the patch seems to obviate the need for oral opioids after discharge. Nausea and vomiting were a concern - as expected -, but only at 24 and 36 hours. On the other hand nausea did not seem to affect activity, as there was a gradual increase in activity score over time.

摘要

在过去十年中,与阿片类药物相关的死亡人数呈指数级增长。事实证明,这与强效阿片类药物的医疗处方率上升有关。我们研究了在腘神经阻滞下进行拇外翻手术后,仅使用一片透皮芬太尼贴剂而不口服阿片类药物,疼痛是否能得到充分控制。在这项前瞻性观察研究中,我们对100例行第一跖骨截骨矫正术的患者进行了前瞻性研究,调查了不良反应及额外止痛药物的需求。在超声引导下进行腘神经阻滞前1小时,即手术前1小时应用透皮芬太尼贴剂。患者每6小时填写一份问卷,以评估疼痛程度(视觉模拟评分法[VAS]评分)、恶心程度(术后恶心呕吐评分法[PONV]评分)、活动情况(活动及行走评分)以及额外药物的摄入情况。术后疼痛得到了良好控制(平均VAS评分为2.53)。术后36小时记录到的最大平均VAS评分为3.93。63.8%的患者疼痛程度低于预期。患者未报告重大不良反应。恶心主要为轻度,大多数患者报告对日常活动“无影响”或“有时有影响”。在外科医生需要意识到过度使用强效阿片类药物威胁的时代,在拇外翻手术中,使用一片透皮芬太尼贴剂联合超声引导下神经阻滞可能是一个不错的选择。使用该贴剂似乎可以避免出院后口服阿片类药物的需求。恶心和呕吐是令人担忧的问题——正如预期的那样——但仅在术后24小时和36小时出现。另一方面,恶心似乎并未影响活动,因为随着时间的推移活动评分逐渐增加。

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