人类20号染色体上腺苷脱氨酶基因与S-腺苷同型半胱氨酸水解酶基因之间的连锁关系。

Linkage relationship between the genes for adenosine deaminase and S-adenosyl-homocysteine hydrolase on human chromosome 20.

作者信息

Bissbort S, Hitzeroth H W, van den Berg C T, Wienker T F

机构信息

Department of Chemical Pathology, University of Pretoria, South Africa.

出版信息

Hum Genet. 1987 Nov;77(3):277-9. doi: 10.1007/BF00284485.

DOI:10.1007/BF00284485

PMID:3679211

Abstract

The genes for adenosine deaminase (ADA) and S-adenosyl homocysteine hydrolase (AHCY or SAHH) are known to be syntenic and within measurable distance from each other, on chromosome 20 in man. In the present study an informative family is described in which the recombination fraction (theta) between the respective genes is estimated to be about 0.18. Together with the published finding of theta = 0.15 (Eiberg and Mohr 1985) in informative Danish families, the recombination fraction for the pooled data is calculated to be theta = 0.14 (in men), theta = 0.08 (in women) and theta = 0.13 (both sexes taken together).

摘要

已知腺苷脱氨酶（ADA）基因和S-腺苷同型半胱氨酸水解酶（AHCY或SAHH）基因在人类20号染色体上是同线的，且彼此之间的距离可测。在本研究中，描述了一个信息丰富的家系，其中估计各基因之间的重组率（θ）约为0.18。结合丹麦信息丰富家系中已发表的θ = 0.15（艾伯格和莫尔，1985年）这一发现，计算得出合并数据的重组率为：男性θ = 0.14，女性θ = 0.08，男女合计θ = 0.13。