Fares Jawad, Davis Zachary B, Rechberger Julian S, Toll Stephanie A, Schwartz Jonathan D, Daniels David J, Miller Jeffrey S, Khatua Soumen
Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Northwestern Medicine Malnati Brain Tumor Institute, Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
NPJ Precis Oncol. 2023 Feb 15;7(1):17. doi: 10.1038/s41698-023-00356-1.
Despite advances in treatment regimens that comprise surgery, chemotherapy, and radiation, outcome of many brain tumors remains dismal, more so when they recur. The proximity of brain tumors to delicate neural structures often precludes complete surgical resection. Toxicity and long-term side effects of systemic therapy remain a concern. Novel therapies are warranted. The field of NK cell-based cancer therapy has grown exponentially and currently constitutes a major area of immunotherapy innovation. This provides a new avenue for the treatment of cancerous lesions in the brain. In this review, we explore the mechanisms by which the brain tumor microenvironment suppresses NK cell mediated tumor control, and the methods being used to create NK cell products that subvert immune suppression. We discuss the pre-clinical studies evaluating NK cell-based immunotherapies that target several neuro-malignancies and highlight advances in molecular imaging of NK cells that allow monitoring of NK cell-based therapeutics. We review current and ongoing NK cell based clinical trials in neuro-oncology.
尽管包含手术、化疗和放疗的治疗方案取得了进展，但许多脑肿瘤的治疗结果仍然不佳，复发时更是如此。脑肿瘤与精细神经结构的 proximity 常常使完全手术切除无法实现。全身治疗的毒性和长期副作用仍然令人担忧。需要新的治疗方法。基于自然杀伤（NK）细胞的癌症治疗领域呈指数级增长，目前构成了免疫治疗创新的一个主要领域。这为治疗脑部癌性病变提供了一条新途径。在本综述中，我们探讨了脑肿瘤微环境抑制NK细胞介导的肿瘤控制的机制，以及用于制造颠覆免疫抑制的NK细胞产品的方法。我们讨论了评估针对几种神经恶性肿瘤的基于NK细胞的免疫疗法的临床前研究，并强调了可用于监测基于NK细胞疗法的NK细胞分子成像方面的进展。我们回顾了神经肿瘤学中当前和正在进行的基于NK细胞的临床试验。
