Department of Biology, The City College of New York, New York, NY, USA.
Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
Adv Exp Med Biol. 2023;1404:41-63. doi: 10.1007/978-3-031-22997-8_3.
The Vibrio Type VI Secretion System (T6SS) is a harpoon-like nanomachine that serves as a defense system and is encoded by approximately 25% of all gram-negative bacteria. In this chapter, we describe the structure of the T6SS in different Vibrio species and outline how the use of different T6SS effector and immunity proteins control kin selection. We summarize the genetic loci that encode the structural elements that make up the Vibrio T6SSs and how these gene clusters are regulated. Finally, we provide insights into T6SS-based competitive dynamics, the role of T6SS genetic exchange in those competitive dynamics, and roles for the Vibrio T6SS in virulence.
Vibrio 型 VI 分泌系统 (T6SS) 是一种类似鱼叉的纳米机器，作为防御系统存在，大约编码了所有革兰氏阴性菌的 25%。在这一章中，我们描述了不同弧菌物种中 T6SS 的结构，并概述了不同 T6SS 效应物和免疫蛋白的使用如何控制亲缘选择。我们总结了编码构成弧菌 T6SS 的结构元件的遗传基因座，以及这些基因簇是如何被调控的。最后，我们提供了关于基于 T6SS 的竞争动态、T6SS 遗传交换在这些竞争动态中的作用以及 Vibrio T6SS 在毒力中的作用的见解。
