Department of Active Life Promotion Sciences, Graduate School of Medicine, Hirosaki University, Aomori, Japan.
Health & Wellness Products Research Laboratories, Kao Corporation, Tokyo, Japan.
Int J Obes (Lond). 2023 May;47(5):375-381. doi: 10.1038/s41366-023-01274-9. Epub 2023 Feb 16.
Several studies have reported that the coronavirus disease (COVID-19) pandemic has increased sedentary behaviour and obesity; however, these analyses used self-reported data, and the association between sedentary behaviour and visceral fat and adipocytokines during the COVID-19 pandemic remains unclear. We aimed to investigate the association of the COVID-19 pandemic with objectively measured sedentary behaviour and these obesity-related factors.
Longitudinal analysis was conducted on 257 Japanese participants who underwent health check-ups in 2018 before and in 2020 during the COVID-19 pandemic. For both time points, sedentary behaviour was measured using an accelerometer for at least 7 days, visceral fat area (VFA) was measured using abdominal bioelectrical impedance analysis, and blood adiponectin level was measured using latex agglutination turbidimetric immunoassay. Multiple linear regression was performed to determine the association between sedentary behaviour and these outcomes.
Compared with data in 2018, sedentary behaviour and VFA were significantly increased (P < 0.001, P = 0.006) whereas adiponectin level was significantly decreased (P < 0.001) in 2020. Increased sedentary behaviour was significantly associated with an increase in VFA (β = 3.85, 95% CI 1.22-6.49, P = 0.004) and a decrease in adiponectin level (β = -0.04, 95% CI -0.06 to -0.01, P = 0.005). However, the association of sedentary behaviour with adiponectin level was not significant after considering the effects of VFA.
The COVID-19 pandemic was associated with objectively measured sedentary behaviour and obesity-related factors in Japanese adults. Additionally, an increase in sedentary behaviour was associated with an increase in VFA, whereas the association of sedentary behaviour with adiponectin was partly mediated by VFA. These results suggest that avoiding increasing sedentary time is important to prevent visceral adiposity thereby ameliorating adiponectin, especially during behavioural limitations such as the COVID-19 pandemic.
多项研究报告称，冠状病毒病（COVID-19）大流行增加了久坐行为和肥胖；然而，这些分析使用了自我报告的数据，并且 COVID-19 大流行期间久坐行为与内脏脂肪和脂肪细胞因子之间的关联尚不清楚。我们旨在研究 COVID-19 大流行与客观测量的久坐行为以及这些肥胖相关因素之间的关联。
对 2018 年和 2020 年 COVID-19 大流行期间接受健康检查的 257 名日本参与者进行了纵向分析。在这两个时间点，使用加速度计测量至少 7 天的久坐行为，使用腹部生物电阻抗分析测量内脏脂肪面积（VFA），并使用乳胶凝集浊度免疫分析测量血脂联素水平。进行多元线性回归以确定久坐行为与这些结果之间的关系。
与 2018 年的数据相比，2020 年的久坐行为和 VFA 显著增加（P<0.001，P=0.006），而脂联素水平显著降低（P<0.001）。增加的久坐行为与 VFA 的增加显著相关（β=3.85，95%CI 1.22-6.49，P=0.004）和脂联素水平的降低显著相关（β=-0.04，95%CI -0.06 至 -0.01，P=0.005）。然而，考虑到 VFA 的影响后，久坐行为与脂联素水平之间的关联并不显著。
COVID-19 大流行与日本成年人中客观测量的久坐行为和肥胖相关因素有关。此外，久坐行为的增加与 VFA 的增加有关，而久坐行为与脂联素的关联部分由 VFA 介导。这些结果表明，在行为受限期间（如 COVID-19 大流行期间），避免增加久坐时间对于预防内脏肥胖从而改善脂联素很重要。
