Bruno Guglielmo, Chioma Roberto, Storti Enrico, De Luca Giovanni, Fantinato Margherita, Antonazzo Patrizio, Pierro Maria
Neonatal and Paediatric Intensive Care Unit, M. Bufalini Hospital, AUSL Romagna, Cesena, Italy.
Paediatric Unit, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy.
Front Pediatr. 2023 Jan 30;10:1112313. doi: 10.3389/fped.2022.1112313. eCollection 2022.
Bronchopulmonary dysplasia (BPD) is one of the most common complications of premature birth. The current definition of BPD is based on the duration of oxygen therapy and/or respiratory support. Among the pitfalls of all the diagnostic definitions, the lack of a proper pathophysiologic classification makes it difficult to choose an appropriate drug strategy for BPD. In this case report, we describe the clinical course of four premature infants, admitted to the neonatal intensive care unit, for whom the use of lung and cardiac ultrasound was an integral part of the diagnostic and therapeutic process. We describe, for the first time to our knowledge, four different cardiopulmonary ultrasound patterns of evolving and established chronic lung disease of prematurity and the consequent therapeutic choices. This approach, if confirmed in prospective studies, may guide the personalized management of infants suffering from evolving and established BPD, optimizing the chances of success of the therapies and at the same time reducing the risk of exposure to inadequate and potentially harmful drugs.
支气管肺发育不良（BPD）是早产最常见的并发症之一。BPD的当前定义基于氧疗和/或呼吸支持的持续时间。在所有诊断定义的缺陷中，缺乏适当的病理生理分类使得难以选择合适的BPD药物治疗策略。在本病例报告中，我们描述了四名入住新生儿重症监护病房的早产儿的临床过程，对于他们而言，肺部和心脏超声检查是诊断和治疗过程中不可或缺的一部分。据我们所知，我们首次描述了早产儿慢性肺病进展期和已确诊期的四种不同心肺超声模式以及相应的治疗选择。如果在前瞻性研究中得到证实，这种方法可能会指导患有进展期和已确诊BPD的婴儿的个性化管理，优化治疗成功的机会，同时降低接触不适当和潜在有害药物的风险。
