Richter E, Schulze J, Zwickenpflug W
Walther Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München, Federal Republic of Germany.
IARC Sci Publ. 1987(84):156-8.
The omega- and omega-1-hydroxylation of N-nitrosodi-n-butylamine (NDBA) has been studied in microsomes from rat liver, lung, intestine and kidney. Both reactions followed at least two enzyme kinetics with low (2-10 microM) and high (1 mM) Km values. Whereas omega-1-hydroxylation was the predominant pathway in liver, omega-hydroxylation was more important in extrahepatic tissues. First-pass metabolism of NDBA in lungs and intestinal mucosa may be of importance in the development of urinary bladder tumours in rats.
已对大鼠肝脏、肺、肠道和肾脏微粒体中N-亚硝基二正丁胺（NDBA）的ω-和ω-1-羟基化作用进行了研究。两种反应均遵循至少两种酶动力学，其米氏常数（Km值）较低（2 - 10微摩尔/升）和较高（1毫摩尔/升）。虽然ω-1-羟基化是肝脏中的主要途径，但ω-羟基化在肝外组织中更为重要。NDBA在肺和肠黏膜中的首过代谢可能在大鼠膀胱肿瘤的发生中起重要作用。
