Zhou Yu, Ma Ruixia, Luo Jiangbo, Wang Zhikai, Yang Pei
Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750001, China.
Department of Otorhinolaryngology Head and Neck Surgery, The First People's Hospital of Yinchuan, Yinchuan, Ningxia 750001, China.
Evid Based Complement Alternat Med. 2023 Feb 6;2023:5628551. doi: 10.1155/2023/5628551. eCollection 2023.
This prospective randomized controlled analysis aimed to assess the changes in laryngopharyngeal reflux (LPR) in children with adenoid hypertrophy (AH). Study design: a prospective, randomized, and controlled analysis.
The reflux symptom index (RSI) and the reflux finding score (RFS) scores were used to evaluate the laryngopharyngeal reflux changes in children diagnosed with adenoid hypertrophy. The pepsin concentration in salivary samples was examined, and the positive pepsin was used to assess the sensitivity and specificity of RSI, RFS, and RSI combined with RFS in forecasting LPR.
In 43 children with AH, the sensitivity of the RSI and RFS scale (used alone or in combination) in diagnosing pharyngeal reflux in children with adenoid hypertrophy was lower. Pepsin expression was identified in 43 items of salivary samples, with a total positive rate of 69.77%, most of which were optimistic. The expression level of pepsin was positively correlated with the grade of adenoid hypertrophy ( = 0.576, < 0.01). Based on the positive rate of pepsin, we found that the sensitivity and specificity of RSI and RFS were 5.77%, 35.03%, and 91.74%, 55.89%. Moreover, there was a noticeable distinction in the number of acid reflux episodes between the LPR-positive and LPR-negative groups.
There is a special connection between LPR change and children's AH. LPR exerts a crucial role in the progression of children's AH. Because of the low sensitivity of RSI and RFS, it is not suitable for LPR children to choose AH.
本前瞻性随机对照分析旨在评估腺样体肥大（AH）患儿喉咽反流（LPR）的变化。研究设计：前瞻性、随机、对照分析。
采用反流症状指数（RSI）和反流发现评分（RFS）来评估诊断为腺样体肥大患儿的喉咽反流变化。检测唾液样本中的胃蛋白酶浓度，并用胃蛋白酶阳性来评估RSI、RFS及RSI联合RFS预测LPR的敏感性和特异性。
在43例腺样体肥大患儿中，RSI和RFS量表（单独或联合使用）诊断腺样体肥大患儿咽反流的敏感性较低。在43份唾液样本中检测到胃蛋白酶表达，总阳性率为69.77%，大多数为阳性。胃蛋白酶表达水平与腺样体肥大程度呈正相关（r = 0.576，P < 0.01）。基于胃蛋白酶阳性率，我们发现RSI和RFS的敏感性和特异性分别为5.77%、35.03%以及91.74%、55.89%。此外，LPR阳性组和LPR阴性组的酸反流发作次数存在显著差异。
LPR变化与儿童腺样体肥大之间存在特殊联系。LPR在儿童腺样体肥大的进展中起关键作用。由于RSI和RFS敏感性较低，腺样体肥大患儿不宜选择LPR。
