Challis B C, Fernandes M H, Glover B R, Latif F
Chemistry Department, Imperial College, London, United Kingdom.
IARC Sci Publ. 1987(84):308-14.
A versatile synthesis of diazopeptides is reported and several new compounds described. It is shown that diazopeptides form readily from gaseous nitrogen dioxide in both neutral buffers and human blood. In these media, diazopeptides are sufficiently stable (half-time 0.5-30 h) to qualify as potential circulating carcinogens.
报道了重氮肽的一种通用合成方法,并描述了几种新化合物。结果表明,在中性缓冲液和人血液中,二氧化氮气体都能很容易地形成重氮肽。在这些介质中,重氮肽具有足够的稳定性(半衰期为0.5 - 30小时),有资格成为潜在的循环致癌物。