Science and Technology Innovation Center, Guangyuan Central Hospital, Guangyuan 628000, China.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
J Mater Chem B. 2023 Mar 22;11(12):2631-2637. doi: 10.1039/d2tb02686d.
Based on disulfide-enriched multiblock copolymer vesicles, we present a straightforward sequential drug delivery system with dual-redox response that releases hydrophilic doxorubicin hydrochloride (DOX·HCl) and hydrophobic paclitaxel (PTX) under oxidative and reductive conditions, respectively. When compared to concurrent therapeutic delivery, the spatiotemporal control of drug release allows for an improved combination antitumor effect. The simple and smart nanocarrier has promising applications in the field of cancer therapy.
基于富含二硫键的多嵌段共聚物囊泡，我们提出了一种简单的顺序药物传递系统，具有双重氧化还原响应，分别在氧化和还原条件下释放亲水性盐酸多柔比星 (DOX·HCl) 和疏水性紫杉醇 (PTX)。与同时治疗递送相比，药物释放的时空控制可以改善联合抗肿瘤效果。这种简单而智能的纳米载体在癌症治疗领域具有广阔的应用前景。
