Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Institute of Life Science and Green Development, Chemical Biology Key Laboratory of Hebei Province, Hebei Key Laboratory of Precise Imaging of Inflammation Related Tumors, College of Chemistry & Environmental Science, Hebei University, Baoding, 071002, P. R. China.
J Mater Chem B. 2023 Mar 8;11(10):2249-2257. doi: 10.1039/d2tb02548e.
Chemodynamic therapy (CDT) has shown potential for important applications in tumor precision therapy, but insufficient endogenous hydrogen peroxide (HO), overexpressed glutathione (GSH) and a weak Fenton-reaction rate greatly reduced the efficacy of CDT. Herein, a metal-organic framework (MOF) based bimetallic nanoprobe with self-supplying HO was developed for enhancing CDT with triple amplification, in which ultrasmall gold nanoparticles (AuNPs) were deposited on Co-based MOFs (ZIF-67), and manganese dioxide (MnO) nanoshells were coated to form a ZIF-67@AuNPs@MnO nanoprobe. In the tumor microenvironment, MnO depleted overexpressed GSH to produce Mn, and the bimetallic Co/Mn nanoprobe accelerated the Fenton-like reaction rate. Moreover, by catalyzing glucose ultrasmall AuNPs, the self-supplying HO further promoted hydroxyl radical (˙OH) generation. Compared with those of ZIF-67 and ZIF-67@AuNPs, the ˙OH yield of ZIF-67@AuNPs@MnO obviously increased, due to which the cell viability decreased to 9.3%, and the tumor completely disappeared, indicating the enhanced CDT performance of the ZIF-67@AuNPs@MnO nanoprobe.
化学动力学疗法（CDT）在肿瘤精准治疗中有很大的应用潜力，但内源性过氧化氢（HO）不足、谷胱甘肽（GSH）过表达和较弱的芬顿反应速率大大降低了 CDT 的疗效。在此，开发了一种基于金属有机框架（MOF）的双金属纳米探针，具有自供应 HO，用于通过三重放大增强 CDT，其中超小的金纳米粒子（AuNPs）沉积在基于 Co 的 MOFs（ZIF-67）上，并涂覆了二氧化锰（MnO）纳米壳以形成 ZIF-67@AuNPs@MnO 纳米探针。在肿瘤微环境中，MnO 耗尽过表达的 GSH 以产生 Mn，双金属 Co/Mn 纳米探针加速了类芬顿反应速率。此外，通过催化葡萄糖，超小的 AuNPs 进一步促进了羟基自由基（˙OH）的生成。与 ZIF-67 和 ZIF-67@AuNPs 相比，ZIF-67@AuNPs@MnO 的˙OH 产率明显增加，因此细胞活力降低至 9.3%，肿瘤完全消失，表明 ZIF-67@AuNPs@MnO 纳米探针增强了 CDT 性能。
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