Scansetti G, Buglione E, Massiccio M M, Greghi D, Inglese L, Pisani W, Pavan I
Servizio di Tossicologia ed Epidemiologia Industriale, Istituto di Medicina del Lavoro, Università di Torino, Italy.
Int Arch Occup Environ Health. 1987;59(6):537-43. doi: 10.1007/BF00377916.
Sixteen rubber vulcanizers using IPPD as anti-oxidant were monitored for the presence of the parent compound in the urine during two consecutive working weeks using HPLC for analysis. At least two components in the excretion kinetics could be demonstrated: a fast one, as end-shift urinary concentrations significantly exceeded before-shift ones, and a less rapid one, as before-shift values at the end of the week significantly differed from those determined at the beginning. A skin absorption experiment was also performed. It demonstrated three components in the excretion kinetics, with apparent half-times of approximately 3, 7 and 24 h. Excretion ceased 7 d after skin exposure.
在连续两个工作周内，使用高效液相色谱法（HPLC）分析，对16名使用N-异丙基-N'-苯基对苯二胺（IPPD）作为抗氧化剂的橡胶硫化工人的尿液中母体化合物的存在情况进行了监测。排泄动力学中至少可证明有两种成分：一种是快速成分，因为班末尿液浓度显著超过班前浓度；另一种是速度较慢的成分，因为周末班前值与开始时测定的值有显著差异。还进行了一项皮肤吸收实验。实验证明排泄动力学中有三种成分，表观半衰期约为3、7和24小时。皮肤接触7天后排泄停止。
