Schück O
Institute for Clinical and Experimental Medicine, Prague, CSSR.
Int J Clin Pharmacol Ther Toxicol. 1987 Sep;25(9):476-8.
The changes in plasma protein binding of drugs caused by chronic renal failure have been evaluated with respect to the calculation of their total plasma clearance. Theoretical analysis suggests that if the plasma protein binding of the drug is high and if it is excreted predominantly by the kidneys (e.g., cefoxitin, cloxacillin), negligible changes in the plasma protein binding caused by chronic uremia can be the source of a significant error in adjustment of its dosing regimen. A formula for the calculation of changes in total plasma clearance with respect to changes of their plasma protein binding has been recommended.
关于药物总血浆清除率的计算，已经评估了慢性肾衰竭引起的药物血浆蛋白结合变化。理论分析表明，如果药物的血浆蛋白结合率很高，并且主要通过肾脏排泄（例如头孢西丁、氯唑西林），那么慢性尿毒症引起的血浆蛋白结合变化可忽略不计，这可能是调整其给药方案时产生重大误差的原因。已推荐了一个根据血浆蛋白结合变化来计算总血浆清除率变化的公式。
