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2014-2019 年美国数据库中 2 型糖尿病患者新使用胰高血糖素样肽-1 受体激动剂的模式:处方医生和患者特征。

Patterns of new glucagon-like peptide-1 receptor agonist use in patients with type 2 diabetes during 2014-2019 from a US database: prescriber and patient characteristics.

机构信息

University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

出版信息

J Diabetes. 2023 Feb;15(2):190-195. doi: 10.1111/1753-0407.13363.

DOI:10.1111/1753-0407.13363
PMID:36796312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9934953/
Abstract

This study demonstrates that initiation of glucagon‐like peptide‐1 receptor agonists among individuals with type 2 diabetes (T2D), including those with concomitant atherosclerotic cardiovascular disease (ASCVD), has remained low in the United States between 2014 and 2019, despite clinical evidence supporting their use for cardiovascular risk reduction. These findings add to the existing literature to highlight a gap in adherence to current practice guidelines, which suggests that most patients with T2D and ASCVD in the United States may not be receiving optimal risk‐reducing therapies.

摘要

这项研究表明,尽管有临床证据支持使用胰高血糖素样肽-1 受体激动剂(GLP-1RA)来降低心血管风险,但在美国,2014 年至 2019 年间,2 型糖尿病(T2D)患者(包括合并动脉粥样硬化性心血管疾病(ASCVD)的患者)开始使用 GLP-1RA 的比例仍然很低。这些发现增加了现有文献的内容,突出了对当前实践指南的遵从性存在差距,这表明美国大多数患有 T2D 和 ASCVD 的患者可能并未接受最佳的降低风险治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d82/9934953/f7e3a5c94b93/JDB-15-190-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d82/9934953/f7e3a5c94b93/JDB-15-190-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d82/9934953/f7e3a5c94b93/JDB-15-190-g001.jpg

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Patterns of new glucagon-like peptide-1 receptor agonist use in patients with type 2 diabetes during 2014-2019 from a US database: prescriber and patient characteristics.2014-2019 年美国数据库中 2 型糖尿病患者新使用胰高血糖素样肽-1 受体激动剂的模式:处方医生和患者特征。
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本文引用的文献

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Diabetes Care. 2022 Jan 1;45(Suppl 1):S144-S174. doi: 10.2337/dc22-S010.
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Real-world use of cardioprotective glucose-lowering drugs in patients with type 2 diabetes and cardiovascular disease: A Danish nationwide cohort study, 2012 to 2019.2012 年至 2019 年丹麦全国队列研究:2 型糖尿病和心血管疾病患者心脏保护降糖药物的真实世界应用。
Diabetes Obes Metab. 2021 Feb;23(2):520-529. doi: 10.1111/dom.14245. Epub 2020 Nov 17.
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2020 Expert Consensus Decision Pathway on Novel Therapies for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes: A Report of the American College of Cardiology Solution Set Oversight Committee.
Residual cardiovascular risk, use of standard care treatments, and achievement of treatment goals in patients with cardiovascular disease.
心血管疾病患者的残余心血管风险、标准治疗方法的使用及治疗目标的达成情况。
Int J Cardiol Cardiovasc Risk Prev. 2023 Jul 21;18:200198. doi: 10.1016/j.ijcrp.2023.200198. eCollection 2023 Sep.
2020年2型糖尿病患者降低心血管风险新型疗法专家共识决策路径:美国心脏病学会解决方案集监督委员会报告
J Am Coll Cardiol. 2020 Sep 1;76(9):1117-1145. doi: 10.1016/j.jacc.2020.05.037. Epub 2020 Aug 5.
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Antihyperglycemic Therapies With Expansions of US Food and Drug Administration Indications to Reduce Cardiovascular Events: Prescribing Patterns Within an Academic Medical Center.美国食品和药物管理局扩大适应证以降低心血管事件的抗高血糖治疗:学术医疗中心的处方模式。
J Cardiovasc Pharmacol. 2020 Sep;76(3):313-320. doi: 10.1097/FJC.0000000000000864.
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Changes in SGLT2i and GLP-1RA real-world initiator profiles following cardiovascular outcome trials: A Danish nationwide population-based study.SGLT2i 和 GLP-1RA 真实世界起始治疗方案在心血管结局试验后的变化:一项丹麦全国基于人群的研究。
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Diabetes Care. 2020 Apr;43(4):921-924. doi: 10.2337/dc19-1943. Epub 2020 Feb 10.
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Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial.度拉糖肽与 2 型糖尿病患者的心血管结局(REWIND):一项双盲、随机、安慰剂对照试验。
Lancet. 2019 Jul 13;394(10193):121-130. doi: 10.1016/S0140-6736(19)31149-3. Epub 2019 Jun 9.
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Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.口服司美格鲁肽与 2 型糖尿病患者的心血管结局。
N Engl J Med. 2019 Aug 29;381(9):841-851. doi: 10.1056/NEJMoa1901118. Epub 2019 Jun 11.
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Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).2018 年美国糖尿病协会(ADA)和欧洲糖尿病研究协会(EASD)的共识报告:2 型糖尿病患者高血糖的管理。
Diabetologia. 2018 Dec;61(12):2461-2498. doi: 10.1007/s00125-018-4729-5.
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Antidiabetic treatment patterns and specialty care utilization among patients with type 2 diabetes and cardiovascular disease.2 型糖尿病合并心血管疾病患者的降糖治疗模式和专科治疗利用情况。
Cardiovasc Diabetol. 2018 Apr 10;17(1):54. doi: 10.1186/s12933-018-0699-7.