Department of Neurosurgery, Umraniye Training and Research Hospital, Istanbul, Turkey.
J Coll Physicians Surg Pak. 2023 Feb;33(2):136-140. doi: 10.29271/jcpsp.2023.02.136.
To analyse the relationship between peritumoural oedema volume and tumour volume in relation to the impact of metastatic posterior fossa tumour survival rates.
An observational study.
Umraniye Training and Research Hospital, İstanbul, Turkey, from 2011-2021.
Fifty-six cancer patients who had been operated upon for cerebellar metastases were analysed retrospectively. To investigate the effect of oedema on survival, patients with a single cerebellar metastasis were evaluated retrospectively. Those patients had a single metastasis located in the cerebellum and did not receive radiotherapy or corticosteroids before surgery. OsiriX MD DICOM viewer was used to calculate the volumes of the tumour and the oedema using fluid-attenuated inversion recovery (FLAIR) and contrast-enhanced magnetic resonance imaging (MRI). The patients were separated into two groups, and the cut-off limit for the oedema to-tumour ratio was set to two. Survival analysis was performed on the two groups.
When the primary sites of the tumours were evaluated, 60.7% were located in the lungs (n = 34), 10.7% were located in the breasts (n = 6), 10.7% were located in the gastrointestinal tract (n = 6), 7.1% were located in the renal region (n = 4), 5.4% were located in the gynaecologic tract (n = 3), and 5.4% were located in other parts of the body (n = 3). A univariate analysis showed that overall survival duration was significantly longer in the subgroup with breast cancer (83.3%) and in those patients with a peritumoural oedema volume to tumour volume ratio of less than two (27.6%, p <0.05). Negative prognostic factors were lung cancer and high peritumoural oedema volume.
Significant peritumoural oedema was linked to a poor prognosis for cancer patients with a single cerebellar metastasis, especially with lung cancer as the primary source.
Cerebellar metastases, Cerebellum, OsiriX MD, Tumour volume.
分析瘤周水肿体积与肿瘤体积之间的关系，以及其对转移后颅窝肿瘤生存率的影响。
观察性研究。
土耳其伊斯坦布尔厄姆拉尼耶培训与研究医院，2011-2021 年。
回顾性分析了 56 例因小脑转移而接受手术的癌症患者。为了研究水肿对生存率的影响，回顾性评估了单一小脑转移的患者。这些患者仅有一个位于小脑的单一转移灶，且在手术前未接受放疗或皮质类固醇治疗。使用 OsiriX MD DICOM 查看器，使用液体衰减反转恢复（FLAIR）和对比增强磁共振成像（MRI）计算肿瘤和水肿的体积。将患者分为两组，将水肿与肿瘤比值的截止值设定为 2。对两组患者进行生存分析。
当评估肿瘤的原发部位时，60.7%（n=34）位于肺部，10.7%（n=6）位于乳房，10.7%（n=6）位于胃肠道，7.1%（n=4）位于肾脏区域，5.4%（n=3）位于妇科，5.4%（n=3）位于其他部位。单因素分析显示，乳腺癌亚组患者的总生存时间明显更长（83.3%），且瘤周水肿体积与肿瘤体积比值小于 2 的患者（27.6%，p<0.05）的生存时间也更长。负预后因素为肺癌和高瘤周水肿体积。
显著的瘤周水肿与单一小脑转移的癌症患者预后不良相关，尤其是以肺癌为原发灶者。
小脑转移瘤；小脑；OsiriX MD；肿瘤体积。
