中学生外周血清炎症细胞因子与儿童期虐待的性别和年龄特异性关联。
Gender- and age-specific associations of childhood maltreatment with peripheral serum inflammatory cytokines in middle school students.
机构信息
Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, Anhui, China.
出版信息
Front Immunol. 2023 Jan 31;14:1067291. doi: 10.3389/fimmu.2023.1067291. eCollection 2023.
BACKGROUND
The impact of childhood maltreatment on multiple inflammatory cytokines among middle school students remains to be elucidated. This study aimed to examine the associations of different types of childhood maltreatment with peripheral serum inflammatory cytokines (interleukin-10, interleukin-1β, interleukin-6, interleukin-8, and tumor necrosis factor-α) in middle school students, and to explore the differences in these associations between boys and girls and between late (≥15 and<20 years) and early (≥11 and <15 years) adolescence.
METHODS
A total of 1122 students were recruited from a boarding middle school. Each participant was asked to respond to a detailed questionnaire on childhood maltreatment, from whom one blood sample was drawn venous blood.
RESULTS
In the overall sample there was no association between childhood maltreatment and peripheral serum inflammatory cytokines; (2) emotional abuse was significantly correlated with IL-1β only in girls ( = -0.16; 95% CI, -0.28-0.03; = 0.06); (3) in late adolescence, emotional abuse, emotional neglect, and childhood maltreatment had marked link with IL-8 ( = 0.39; 95%CI, 0.160.63; = 0.01; =0.20; 95% CI, 0.040.37; = 0.08; = 0.50; 95% CI, 0.180.82; = 0.01, respectively).
CONCLUSION
These findings also strengthened an inference regarding the effects of childhood maltreatment on inflammation of students in late adolescence.
背景
童年期虐待对中学生多种炎性细胞因子的影响仍需阐明。本研究旨在探讨不同类型的童年期虐待与中学生外周血血清炎性细胞因子（白细胞介素-10、白细胞介素-1β、白细胞介素-6、白细胞介素-8 和肿瘤坏死因子-α）之间的相关性，并探讨这些相关性在男女生以及青少年晚期（≥15 岁且＜20 岁）和早期（≥11 岁且＜15 岁）之间的差异。
方法
共从一所寄宿制中学招募了 1122 名学生。每位参与者都被要求对童年期虐待情况进行详细问卷调查，并采集一份静脉血样本。
结果
在总体样本中，童年期虐待与外周血血清炎性细胞因子之间无相关性；（2）情绪虐待仅与女生的白细胞介素-1β显著相关（β=-0.16；95%CI，-0.28-0.03；P=0.06）；（3）在青少年晚期，情绪虐待、情感忽视和童年期虐待与白细胞介素-8 有显著关联（β=0.39；95%CI，0.160.63；P=0.01；β=0.20；95%CI，0.040.37；P=0.08；β=0.50；95%CI，0.180.82；P=0.01）。
结论
这些发现进一步证实了童年期虐待对青少年晚期学生炎症的影响。
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