Yang Jiamiao, Zheng Chao, Wang Yan, Yang Ling, Liu Lianyong
Department of Endocrinology, Shanghai Punan Hospital of Pudong New District, Shanghai, People's Republic of China.
Diabetes Metab Syndr Obes. 2023 Feb 10;16:397-407. doi: 10.2147/DMSO.S388919. eCollection 2023.
The present study explores the relationship between glycemic excursion and bone turnover markers.
A total of 250 patients with type 2 diabetes mellitus (T2DM) (142 female and 108 male patients) were enrolled in this study. All participants underwent 72 hours of continuous glycemic monitoring to evaluate the mean amplitude of glycemic excursions (MAGE) of each person. Bone turnover markers and other biochemical data were measured for each patient. Linear regression was performed to explore the relationship between bone turnover markers and glycemic excursion. A value of < 0.05 was considered statistically significant.
MAGE was negatively correlated to N-terminal propeptide of type 1 collagen (P1NP) female: [odds ratios (95% confidence interval) (OR (95% CI)), -2.516 (-5.389, 0.356)]; male: [-2.895, (-6.521, -0.731)] and C-terminal telopeptide fragments of type-I collagen (β-CTX) female [-0.025, (-0.036, 0.005)]; male [-0.043, (-0.082, 0.003)]. MAGE was still negatively correlated with β-CTX female [-0.036, (-0.198, -0.030)]; male [-0.048, (-0.089, -0.007)] after adjusting for clinical data and biochemical indices.
An independent negative relationship between glycemic excursion and bone turnover markers in patients with T2DM was identified in this study.
本研究探讨血糖波动与骨转换标志物之间的关系。
本研究共纳入250例2型糖尿病（T2DM）患者（142例女性患者和108例男性患者）。所有参与者均接受72小时的连续血糖监测，以评估每个人的血糖波动平均幅度（MAGE）。测量每位患者的骨转换标志物和其他生化数据。进行线性回归以探讨骨转换标志物与血糖波动之间的关系。P < 0.05被认为具有统计学意义。
MAGE与1型胶原N端前肽（P1NP）呈负相关，女性：[比值比（95%置信区间）（OR（95%CI）），-2.516（-5.389，0.356）]；男性：[-2.895，（-6.521，-0.731）]，以及与I型胶原C端肽片段（β-CTX），女性[-0.025，（-0.036，0.005）]；男性[-0.043，（-0.082，0.003）]。在调整临床数据和生化指标后，MAGE与β-CTX仍呈负相关，女性[-0.036，（-0.198，-0.030）]；男性[-0.048，（-0.089，-0.007）]。
本研究确定了T2DM患者血糖波动与骨转换标志物之间存在独立的负相关关系。
