碳离子放射治疗头颈部癌症的剂量体积限制：文献综述。
Dose-volume constraints for head-and-neck cancer in carbon ion radiotherapy: A literature review.
机构信息
Gunma University Heavy Ion Medical Center, Maebashi, Gunma, Japan.
Department of Oral and Maxillofacial Surgery and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
出版信息
Cancer Med. 2023 Apr;12(7):8267-8277. doi: 10.1002/cam4.5641. Epub 2023 Feb 17.
BACKGROUND
Carbon ion radiotherapy (CIRT) has been applied in cancer treatment for over 25 years. However, guidelines for dose-volume constraints have not been established yet. The aim of this review is to summarize the dose-volume constraints in CIRT for head-and-neck (HN) cancer that were determined through previous clinical studies based on the Japanese models for relative biological effectiveness (RBE).
METHODS
A literature review was conducted to identify all constraints determined for HN cancer CIRT that are based on the Japanese RBE models.
RESULTS
Dose-volume constraints are reported for 17 organs at risk (OARs), including the brainstem, ocular structures, masticatory muscles, and skin. Various treatment planning strategies are also presented for reducing the dose delivered to OARs.
CONCLUSIONS
The reported constraints will provide assistance during treatment planning to ensure that radiation to OARs is minimized, and thus adverse effects are reduced. Although the constraints are given based on the Japanese RBE models, applying the necessary conversion factors will potentially enable their application by institutions worldwide that use the local effect model for RBE.
背景
碳离子放疗（CIRT）在癌症治疗中已经应用了超过 25 年。然而，剂量-体积限制的指南尚未建立。本综述的目的是总结基于日本相对生物学效应（RBE）模型的头颈部（HN）癌症 CIRT 的剂量-体积限制，这些限制是通过以前的临床研究确定的。
方法
对所有基于日本 RBE 模型确定的 HN 癌症 CIRT 的剂量-体积限制进行了文献回顾。
结果
报告了 17 个危及器官（OARs）的剂量-体积限制，包括脑干、眼部结构、咀嚼肌和皮肤。还提出了各种治疗计划策略，以减少 OAR 接受的剂量。
结论
所报告的限制将有助于在治疗计划期间确保将 OAR 的辐射最小化，从而减少不良反应。尽管这些限制是基于日本 RBE 模型给出的，但通过应用必要的转换因子，那些使用 RBE 的局部效应模型的机构可能会应用这些限制。
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