Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Int J Mol Med. 2023 Mar;51(3). doi: 10.3892/ijmm.2023.5230. Epub 2023 Feb 17.
Ischemic heart disease (IHD) is a prevalent cardiovascular disease characterized by the formation, progression and rupture of atherosclerotic plaque. The Notch signaling pathway is a key mechanism facilitating intercellular coordination. An increasing number of studies have revealed the significance of Notch signaling, particularly as regards Notch1. Of note, the existence of aberrant Notch1 signaling in IHD is universal, suggesting clinical significance. Thus, the present review summarizes the implications of Notch1 signaling in endothelial cells, vascular smooth muscle cells and macrophages in association with the development of IHD. The present review also examined the effects of Notch1 signaling on various remodeling stages of IHD consisting of reendothelialization, neovascularization, and myocardial fibrosis. Moreover, the participation of Notch1 signaling in conventional reperfusion treatments and cardiac regeneration therapies is discussed. On the whole, the present review aims to outline Notch1 signaling as a novel target which may be used to enhance the treatment efficacy for patients with IHD.
缺血性心脏病（IHD）是一种常见的心血管疾病，其特征在于动脉粥样硬化斑块的形成、进展和破裂。Notch 信号通路是促进细胞间协调的关键机制。越来越多的研究揭示了 Notch 信号的重要性，特别是 Notch1。值得注意的是，IHD 中存在异常的 Notch1 信号是普遍存在的，提示其具有临床意义。因此，本综述总结了 Notch1 信号在与 IHD 发展相关的内皮细胞、血管平滑肌细胞和巨噬细胞中的作用。本综述还研究了 Notch1 信号对 IHD 各种重塑阶段的影响，包括再内皮化、新生血管形成和心肌纤维化。此外，还讨论了 Notch1 信号在传统再灌注治疗和心脏再生治疗中的参与。总的来说，本综述旨在概述 Notch1 信号作为一个新的靶点，可能用于提高 IHD 患者的治疗效果。
