Palmer D, Greenberg P, Cornell P, Parker R G
Department of Radiation Oncology, Jonsson Comprehensive Cancer Center, Los Angeles, CA.
Int J Radiat Oncol Biol Phys. 1987 Dec;13(12):1815-20. doi: 10.1016/0360-3016(87)90346-4.
A retrospective analysis of 29 patients with Graves' ophthalmopathy treated from 1973-1986 was undertaken to evaluate the use of radiation therapy (RT). Most patients presented with advanced disease; 20 had been treated with steroids and 8 had undergone prior surgery with orbital decompression. Post-RT evaluation was performed by the patients' Radiation Oncologist, Ophthalmologist, and Endocrinologist with a median follow-up period of 45 months. The overall assessment of the patients' disease was judged as improved with respect to the majority of signs and symptoms in 48%. Soft tissue changes were relieved in 78% and proptosis reduced in 52%. Ophthalmoplegia responded poorly and was improved in only 24%. After RT, 26/29 (90%) of patients have had no further steroid requirements. Thirteen patients underwent surgery for residual signs/symptoms post radiation therapy, indicating that combined modality may be necessary in many patients with advanced disease.
对1973年至1986年期间接受治疗的29例格雷夫斯眼病患者进行了回顾性分析，以评估放射治疗（RT）的应用情况。大多数患者表现为晚期疾病；20例曾接受过类固醇治疗，8例曾接受过眼眶减压手术。放疗后由患者的放射肿瘤学家、眼科医生和内分泌学家进行评估，中位随访期为45个月。48%的患者的疾病总体评估在大多数体征和症状方面被判定为有所改善。78%的患者软组织变化得到缓解，52%的患者眼球突出得到减轻。眼肌麻痹反应较差，仅24%得到改善。放疗后，29例患者中有26例（90%）不再需要类固醇治疗。13例患者因放疗后残留体征/症状接受了手术，这表明对于许多晚期疾病患者可能需要联合治疗。
