Department of Cardiology, University of Medical Sciences, İstanbul, Turkey.
Department of Cardiology, Recep Tayyip Erdogan University, Rize, Turkey.
Angiology. 2024 May;75(5):454-461. doi: 10.1177/00033197231157929. Epub 2023 Feb 17.
High-grade intracoronary thrombus (ICT) burden leads to greater myocardial injury following anterior myocardial infarction (MI). The modified Glasgow prohgnostic score (mGPS) is a novel immune-inflammatory index, calculated by using C-reactive protein (CRP) and albumin levels, was shown to have prognostic value in heart diseases. The present study investigated the role of mGPS in predicting high grade ICT in patients with acute anterior MI admitted between February 2017 and March 2020. Blood samples were obtained at admission and mGPS was calculated. The ICT burden was evaluated visually from angiographic images. Patients were divided into 2 groups according to the ICT burden as high and low. A total of 1132 patients were enrolled: a mean age 61 ± 12.4 years and 370 males (32.7%). Serum albumin was lower, whereas mGPS and CRP were higher in high grade ICT group. CRP (odds ratio (OR): 1.404 95% CI: 1.312-1.502; < .001), albumin (OR: .486; 95% CI: .301-.782 < .001), and mGPS (0 vs ≥ 1) (OR: 7.391; 95% CI: 3.910-13.972; < .001) were independent predictors of high-grade ICT burden in the left anterior descending coronary artery. The mGPS is a novel predictor of high-grade ICT burden and may be useful for risk stratification in patients with acute anterior MI.
高等级冠状动脉血栓（ICT）负担会导致前壁心肌梗死（MI）后的心肌损伤更大。改良格拉斯哥预后评分（mGPS）是一种新的免疫炎症指数，通过使用 C 反应蛋白（CRP）和白蛋白水平计算得出，已被证明在心脏病中有预后价值。本研究旨在探讨 mGPS 在预测 2017 年 2 月至 2020 年 3 月期间因急性前壁 MI 入院的患者中高等级 ICT 中的作用。入院时采集血样并计算 mGPS。通过血管造影图像评估 ICT 负担。根据 ICT 负担将患者分为高和低两组。共纳入 1132 例患者：平均年龄 61±12.4 岁，370 例男性（32.7%）。高等级 ICT 组血清白蛋白较低，而 mGPS 和 CRP 较高。CRP（优势比（OR）：1.404；95%CI：1.312-1.502；<0.001）、白蛋白（OR：0.486；95%CI：0.301-0.782；<0.001）和 mGPS（0 与≥1）（OR：7.391；95%CI：3.910-13.972；<0.001）是左前降支高等级 ICT 负担的独立预测因子。mGPS 是高等级 ICT 负担的一个新的预测因子，可能对急性前壁 MI 患者的危险分层有用。
