Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Vet Ophthalmol. 2023 Sep;26(5):407-413. doi: 10.1111/vop.13074. Epub 2023 Feb 17.
To compare the variability in the duration of action of a single dose of rocuronium or cisatracurium, and duration of subsequent top-up doses in anesthetized dogs.
Thirty dogs requiring ophthalmic surgery with neuromuscular block.
Neuromuscular function was monitored with train-of-four (TOF) and acceleromyography. Dogs received an initial dose of rocuronium 0.6 mg/kg, or cisatracurium 0.15 mg/kg IV, which produced complete neuromuscular block. Upon return of the first response (T1) of TOF, a third of the initial dose was repeated. The duration of the initial dose and its variability were compared between agents. Duration of subsequent top-up doses was assessed with mixed effect models. Spontaneous (from last return of T1) or neostigmine-enhanced (from administration to complete recovery) recovery times were measured for each agent.
Duration of action of the initial dose was [median (range)] 25 (10-60) min with rocuronium and 35 (15-45) min with cisatracurium (p = .231). The variability of rocuronium was 3.25 times larger than cisatracurium (p = .034). Duration of top-up doses did not vary for either agent. Spontaneous recovery was shorter for rocuronium [15 (10-20) min] than cisatracurium [25 (15-45) min] (p = .02). Neostigmine-enhanced recovery times were 5 (5-25) for rocuronium and 10 (5-10) for cisatracurium (p = .491).
Duration of action for a single dose is significantly more variable with rocuronium than cisatracurium. Time to spontaneous recovery was longer for cisatracurium, and cases of unexpectedly long recovery times were observed with both agents. Objective monitoring is recommended.
比较罗库溴铵或顺式阿曲库铵单次给药的作用持续时间和随后追加剂量的持续时间在麻醉犬中的差异。
30 只需要眼科手术且接受神经肌肉阻滞的狗。
使用四脉冲串（TOF）和加速肌电图监测神经肌肉功能。狗接受罗库溴铵 0.6mg/kg 或顺式阿曲库铵 0.15mg/kg 静脉注射，以产生完全的神经肌肉阻滞。当 TOF 的第一个反应（T1）恢复时，重复初始剂量的三分之一。比较两种药物的初始剂量及其变异性。使用混合效应模型评估随后追加剂量的持续时间。测量每个药物的自发（从最后一个 T1 恢复开始）或新斯的明增强（从给药到完全恢复）的恢复时间。
初始剂量的作用持续时间为罗库溴铵 25（10-60）分钟和顺式阿曲库铵 35（15-45）分钟（p=0.231）。罗库溴铵的变异性是顺式阿曲库铵的 3.25 倍（p=0.034）。两种药物的追加剂量持续时间均无差异。罗库溴铵的自发恢复时间[15（10-20）分钟]短于顺式阿曲库铵[25（15-45）分钟]（p=0.02）。新斯的明增强的恢复时间为罗库溴铵 5（5-25）分钟，顺式阿曲库铵 10（5-10）分钟（p=0.491）。
罗库溴铵单次给药的作用持续时间的变异性明显大于顺式阿曲库铵。顺式阿曲库铵的自发恢复时间较长，两种药物均观察到恢复时间异常延长的情况。建议进行客观监测。
