Frydrych Agnieszka M, van Schaijik Bede, Parsons Richard, Kujan Omar
UWA Dental School, The University of Western Australia, Nedlands, WA, Australia.
Medical School, Curtin University, Bentley, WA, Australia.
J Oral Pathol Med. 2023 Mar;52(3):226-231. doi: 10.1111/jop.13415. Epub 2023 Feb 28.
Oral leukoplakia (OL) is one of the most prevalent oral potentially malignant disorders (OPMD). Although there is emerging evidence that quality of life (QoL) is impaired in subjects with OL; studies to date are based on single and heterogenous point-in-time assessments. The aim of this study was to ascertain if QoL scores change over time in individuals diagnosed with OL.
Forty-one individuals with OL were administered the Short Generic Health Questionnaire (SF-12) and the discipline-specific Oral Potentially Malignant Disorder Questionnaire (OPMDQ) at four points in time: at the time of clinical diagnosis, at the post-biopsy review (confirmed diagnosis), and at 3- and 6-month follow-up appointments. Responses were compared between the four time points.
No significant differences were observed in the SF-12 questionnaire scores over time. However, a general improvement in the participants' life quality was evident over the 6-month period under investigation in the domains of psychological and social well-being (p = 0.0027) and effect of treatment on daily life (p = 0.0317) as well as in the total score (p = 0.0005) of the OPMDQ. Age, gender, medical status, tobacco/alcohol use, lesion site, size, the presence of dysplasia and treatment did not impact QoL scores over time.
QoL scores of OL subjects may improve with time. Our results suggest that studies examining QoL in individuals with OL should be controlled for time at which the participants are surveyed.
口腔白斑（OL）是最常见的口腔潜在恶性疾病（OPMD）之一。尽管越来越多的证据表明，OL患者的生活质量（QoL）受到损害；但迄今为止的研究都是基于单一的、异质性的时间点评估。本研究的目的是确定被诊断为OL的个体的QoL评分是否随时间变化。
41名OL患者在四个时间点接受了简短通用健康问卷（SF-12）和特定学科的口腔潜在恶性疾病问卷（OPMDQ）：临床诊断时、活检后复查（确诊）时以及3个月和6个月的随访预约时。比较四个时间点的回答。
SF-12问卷评分随时间未观察到显著差异。然而，在调查的6个月期间，参与者的生活质量在心理和社会幸福感领域（p = 0.0027）、治疗对日常生活的影响（p = 0.0317）以及OPMDQ总分（p = 0.0005）方面有明显改善。年龄、性别、健康状况、烟草/酒精使用、病变部位、大小、发育异常的存在和治疗均未随时间影响QoL评分。
OL患者的QoL评分可能随时间改善。我们的结果表明，在研究OL患者的QoL时，应控制对参与者进行调查的时间。
