Dou Zheng-Yue, Xia Bing, Wang Chao-Yu, Xu Yan-Jie, Zhang Yi-Zhuo
Department of Medical Oncology, Affiliated Hospital of Hebei University, Baoding, People's Republic of China.
Department of Hematology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin, People's Republic of China.
Hematology. 2023 Dec;28(1):2179218. doi: 10.1080/16078454.2023.2179218.
The incidence of MM in most registries remains stable or showing only a slightly increase. However, prevalence of MM is increasing due to the increase in overall survival in the last two decades. The aim of this study was to observe changes in biochemical parameters during the diagnosis and treatment of MM.
A retrospective analysis was made of the biochemical indicators, survival time, and related adverse events of 196 patients with MM.
Of the 196 patients with MM, 26 were diagnosed with DM (DM-MM group) at the first diagnosis, 31 with steroid-induced diabetes mellitus (SID-MM group) during treatment, and 139 without DM (MM group). There was no significant difference between the three groups in the mean age of onset, sex ratio, incidence of hypercalcemia, renal dysfunction, anemia, abnormal lactate dehydrogenase, and median value of D-dimer and fibrinogen during diagnosis and treatment. There was no significant difference in survival time between the SID-MM and MM groups, but there was a significant difference between the DM-MM and MM groups.
There was no significant difference between the three groups in the incidence of hypercalcemia, anemia, and renal function impairment. The survival time of patients with DM was shorter than that of patients without DM.
在大多数登记处，多发性骨髓瘤（MM）的发病率保持稳定或仅略有上升。然而，由于过去二十年总体生存率的提高，MM的患病率正在上升。本研究的目的是观察MM诊断和治疗期间生化参数的变化。
对196例MM患者的生化指标、生存时间及相关不良事件进行回顾性分析。
196例MM患者中，初诊时26例诊断为糖尿病（DM-MM组），治疗期间31例诊断为类固醇诱导的糖尿病（SID-MM组），139例无糖尿病（MM组）。三组在发病平均年龄、性别比、高钙血症发生率、肾功能不全、贫血、乳酸脱氢酶异常以及诊断和治疗期间D-二聚体和纤维蛋白原的中位数方面无显著差异。SID-MM组和MM组的生存时间无显著差异，但DM-MM组和MM组之间存在显著差异。
三组在高钙血症、贫血和肾功能损害的发生率方面无显著差异。糖尿病患者的生存时间短于无糖尿病患者。
