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建立和验证中国中学生自杀倾向的列线图。

Establishment and validation of a nomogram for suicidality in Chinese secondary school students.

机构信息

School of Public Health, Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China.

School of Public Health, Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China.

出版信息

J Affect Disord. 2023 Jun 1;330:148-157. doi: 10.1016/j.jad.2023.02.062. Epub 2023 Feb 18.

Abstract

BACKGROUND

Accurately identifying high-risk of suicide groups and conducting appropriate interventions are important to reduce the risk of suicide. In this study, a nomogram technique was used to develop a predictive model for the suicidality of secondary school students based on four aspects: individual characteristics; health risk behaviors; family factors; and school factors.

METHODS

A total of 9338 secondary school students were surveyed using the stratified cluster sampling method, and subjects were randomly divided into a training set (n = 6366) and a validation set (n = 2728). In the former, the results of the lasso regression and random forest were combined, from which 7 optimal predictors of suicidality were determined. These were used to construct a nomogram. This nomogram's discrimination, calibration, clinical applicability, and generalization were assessed using receiver operating characteristic curves (ROC), calibration curves, decision curve analysis (DCA), and internal validation.

RESULTS

Gender, depression symptoms, self-injury, running away from home, parents' relationship, relationship with father, and academic stress were found to be significant predictors of suicidality. The area under the curve (AUC) of the training set was 0.806, while that of the validation data was 0.792. The calibration curve of the nomogram was close to the diagonal, and the DCA showed the nomogram was clinically beneficial across a range of thresholds of 9-89 %.

LIMITATIONS

Causal inference is limited due to the cross-sectional design.

CONCLUSION

An effective tool was constructed for predicting suicidality among secondary school students, which should help school healthcare personnel assess this information about students and also identify high-risk groups.

摘要

背景

准确识别自杀风险较高的群体并进行适当干预对于降低自杀风险非常重要。本研究采用列线图技术,基于个体特征、健康风险行为、家庭因素和学校因素四个方面,建立中学生自杀倾向预测模型。

方法

采用分层整群抽样方法对 9338 名中学生进行调查,将对象随机分为训练集(n=6366)和验证集(n=2728)。在训练集中,综合lasso 回归和随机森林的结果,确定了自杀倾向的 7 个最优预测因子,并用这些因子构建列线图。采用受试者工作特征曲线(ROC)、校准曲线、决策曲线分析(DCA)和内部验证评估列线图的区分度、校准度、临床适用性和泛化能力。

结果

性别、抑郁症状、自伤、离家出走、父母关系、与父亲的关系和学业压力被认为是自杀倾向的显著预测因子。训练集的曲线下面积(AUC)为 0.806,验证数据的 AUC 为 0.792。列线图的校准曲线接近对角线,DCA 显示列线图在 9-89%的阈值范围内具有临床获益。

局限性

由于横断面设计,因果推断受到限制。

结论

构建了一种有效的中学生自杀倾向预测工具,有助于校医评估学生的自杀倾向信息,并识别高风险群体。

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