Division of Gastroenterology and Hepatology, Department of Internal Medicine (Omori), School of Medicine, Faculty of Medicine, Toho University, 6-11-1 Omori-Nishi, Ota-Ku, Tokyo, 143-8541, Japan.
J Med Ultrason (2001). 2023 Apr;50(2):187-195. doi: 10.1007/s10396-023-01293-z. Epub 2023 Feb 18.
To reveal the ability of S-Map strain elastography to diagnose fibrosis in nonalcoholic fatty liver disease (NAFLD) and to compare its diagnostic ability with that of shear wave elastography (SWE).
Participants were patients with NAFLD who were scheduled to undergo liver biopsy at our institution between 2015 and 2019. A GE Healthcare LOGIQ E9 ultrasound system was used. For S-Map, the right lobe of the liver was visualized in the section where the heartbeat was detected by right intercostal scanning, a 4 × 2-cm region of interest (ROI) was defined at 5 cm from the liver surface, and ROI strain images were acquired. Measurements were repeated six times, with the average taken as the S-Map value. Correlations of S-Map and SWE values with fibrosis stage determined by liver biopsy were analyzed using multiple comparisons. The diagnostic performance of S-Map for fibrosis staging was assessed using receiver operating characteristic curves.
In total, 107 patients (65 men, 42 women; mean age 51 ± 14 years) were analyzed. The S-Map value by fibrosis stage was 34.4 ± 10.9 for F0, 32.9 ± 9.1 for F1, 29.5 ± 5.6 for F2, 26.7 ± 6.0 for F3, and 22.8 ± 4.19 for F4. By fibrosis stage, the SWE value was 1.27 ± 0.25 for F0, 1.39 ± 0.20 for F1, 1.59 ± 0.20 for F2, 1.64 ± 0.17 for F3, and 1.88 ± 0.19 for F4. The diagnostic performance of S-Map (measured by area under the curve) was 0.75 for F2, 0.80 for F3, and 0.85 for F4. The diagnostic performance of SWE (measured by area under the curve) was 0.88 for F2, 0.87 for F3, and 0.92 for F4.
S-Map strain elastography was inferior to SWE in terms of ability to diagnose fibrosis in NAFLD.
揭示 S-Map 应变弹性成像诊断非酒精性脂肪性肝病（NAFLD）纤维化的能力，并比较其与剪切波弹性成像（SWE）的诊断能力。
本研究纳入了 2015 年至 2019 年在我院接受肝活检的 NAFLD 患者。使用通用电气医疗系统 LOGIQ E9 超声系统。对于 S-Map，在右肋间扫描检测到心跳的节段可视化肝脏的右叶，在距肝表面 5cm 处定义 4×2cm 的感兴趣区（ROI），并获取 ROI 应变图像。重复测量 6 次，取平均值作为 S-Map 值。采用多元比较分析 S-Map 和 SWE 值与肝活检确定的纤维化分期的相关性。采用受试者工作特征曲线评估 S-Map 对纤维化分期的诊断性能。
共分析了 107 例患者（65 例男性，42 例女性；平均年龄 51±14 岁）。根据纤维化分期，S-Map 值分别为 F0 期 34.4±10.9、F1 期 32.9±9.1、F2 期 29.5±5.6、F3 期 26.7±6.0 和 F4 期 22.8±4.19。根据纤维化分期，SWE 值分别为 F0 期 1.27±0.25、F1 期 1.39±0.20、F2 期 1.59±0.20、F3 期 1.64±0.17 和 F4 期 1.88±0.19。S-Map（通过曲线下面积衡量）的诊断性能为 F2 期 0.75、F3 期 0.80 和 F4 期 0.85。SWE（通过曲线下面积衡量）的诊断性能为 F2 期 0.88、F3 期 0.87 和 F4 期 0.92。
S-Map 应变弹性成像在诊断 NAFLD 纤维化方面的能力不及 SWE。
