具有可调荧光的光驱动水性耗散准轮烷，可实现可变形纳米组装体

Light-Driven Aqueous Dissipative Pseudorotaxanes with Tunable Fluorescence Enabling Deformable Nano-Assemblies.

作者信息

Hou Xiao-Fang, Chen Xu-Man, Bisoyi Hari Krishna, Qi Qi, Xu Tianchi, Chen Dongzhong, Li Quan

机构信息

Key Lab of High Performance Polymer Materials and Technology of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Institute of Advanced Materials and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.

出版信息

ACS Appl Mater Interfaces. 2023 Mar 1;15(8):11004-11015. doi: 10.1021/acsami.2c20276. Epub 2023 Feb 18.

DOI:10.1021/acsami.2c20276

PMID:36802465

Abstract

Developing an artificial dynamic nanoscale molecular machine that dissipatively self-assembles far from equilibrium is fundamentally important but is significantly challenging. Herein, we report dissipatively self-assembling light-activated convertible pseudorotaxanes (PRs) that show tunable fluorescence and enable deformable nano-assemblies. A pyridinium-conjugated sulfonato-merocyanine derivative (EPMEH) and cucurbit[8]uril (CB[8]) form the 2EPMEH ⊂ CB[8] [3]PR in a 2:1 stoichiometry, which phototransforms into a transient spiropyran containing 1:1 EPSP ⊂ CB[8] [2]PR when exposed to light. The transient [2]PR thermally relaxes (reversibly) to the [3]PR in the dark accompanied by periodic fluorescence changes that include near-infrared emission. Moreover, octahedral and spherical nanoparticles are formed through the dissipative self-assembly of the two PRs, and the Golgi apparatus is dynamically imaged using fluorescent dissipative nano-assemblies.

摘要

开发一种在远离平衡的条件下进行耗散自组装的人工动态纳米级分子机器至关重要，但极具挑战性。在此，我们报道了耗散自组装的光激活可转换准轮烷（PRs），其具有可调谐荧光并能形成可变形的纳米组装体。一种吡啶鎓共轭磺基 - 部花青衍生物（EPMEH）与葫芦[8]脲（CB[8]）以2:1的化学计量比形成2EPMEH ⊂ CB[8] [3]PR，当暴露于光时，其光转化为含有1:1 EPSP ⊂ CB[8] [2]PR的瞬态螺吡喃。瞬态[2]PR在黑暗中热弛豫（可逆地）回到[3]PR，伴随着包括近红外发射在内的周期性荧光变化。此外，通过两种PR的耗散自组装形成了八面体和球形纳米颗粒，并且使用荧光耗散纳米组装体对高尔基体进行了动态成像。